Empagliflozin decreases remnant-like particle cholesterol in type 2 diabetes patients with insulin resistance.

Abstract

AIMS/INTRODUCTION:

Remnant lipoproteins are thought to be atherogenic. Remnant-like particle cholesterol (RLP-C), which reflects the levels of various kinds of remnant lipoproteins in the blood, has a significant correlation with insulin resistance.

MATERIALS AND METHODS:

In the present study, we measured the effect of empagliflozin (EMPA) on the levels of RLP-C, and investigated whether EMPA-mediated change in RLP-C is associated with a change in insulin resistance in type 2 diabetes patients who have insulin resistance.

RESULTS:

Patients were allocated to receive a placebo (n = 51) or EMPA (n = 58) as an add-on treatment. Fasting blood samples were collected before and 12 weeks after this intervention. EMPA significantly decreased glycated hemoglobin, bodyweight, systolic blood pressure, plasma triglycerides, liver transaminases and estimated glomerular filtration rate, and increased high-density lipoprotein cholesterol. Furthermore, EMPA decreased RLP-C and homeostatic model assessment of insulin resistance. In the placebo group, there were no significant changes in these factors except for slight increases in liver transaminases. Multiple regression analysis showed that the change in homeostatic model assessment of insulin resistance (P = 0.0102) and the change in alanine aminotransferase (P = 0.0301) were significantly associated with the change in RLP-C in the EMPA group. The change in RLP-C significantly correlated with the change in homeostatic model assessment of insulin resistance (Pearson correlation coefficient 0.503, 95% confidence interval 0.199-0.719; P = 0.00241).

CONCLUSION:

EMPA decreases RLP-C levels, which is closely associated with amelioration of insulin sensitivity in diabetes patients who have insulin resistance.

• Authors: Sachiko Hattori
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 9 Issue 4 Pg. 870-874 (Jul 2018) ISSN: 2040-1124 [Electronic] Japan
• PMID: 29193767 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Chemical References

• Benzhydryl Compounds
• Blood Glucose
• Glucosides
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Lipoproteins
• Triglycerides
• hemoglobin A1c protein, human
• remnant-like particle cholesterol
• Cholesterol
• empagliflozin

Topics

• Adult
• Aged
• Benzhydryl Compounds (therapeutic use)
• Blood Glucose (analysis)
• Cholesterol (analysis, blood)
• Diabetes Mellitus, Type 2 (complications, drug therapy)
• Female
• Glucosides (therapeutic use)
• Glycated Hemoglobin (analysis)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin Resistance
• Lipoproteins (analysis, blood)
• Male
• Middle Aged
• Prospective Studies
• Triglycerides (analysis, blood)