Abstract | PURPOSE: METHODS: RESULTS: The antigen injection decreased MBP, and increased Hct and vascular permeability in the kidney, lung, mesentery, and intestine, but not in the liver or spleen. Pretreatment with ICI 118,551, propranolol and adrenalectomy, but not atenolol, reduced the survival rate and augmented the increases in Hct and vascular permeability in the kidney, intestine, and lung as compared with the sensitized control group. Pretreatment with terbutaline abolished the antigen-induced alterations. Plasma epinephrine levels were increased significantly in the sensitize control mice. CONCLUSIONS: Blockade of β₂- adrenoceptor can deteriorate systemic anaphylaxis by augmenting hyperpermeability-induced increase in plasma extravasation by inhibiting beneficial effects of epinephrine released from the adrenal glands in anesthetized mice.
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Authors | Wei Yang, Toshishige Shibamoto, Yuhichi Kuda, Tao Zhang, Mamoru Tanida, Yasutaka Kurata |
Journal | Allergy, asthma & immunology research
(Allergy Asthma Immunol Res)
Vol. 10
Issue 1
Pg. 52-61
(Jan 2018)
ISSN: 2092-7355 [Print] Korea (South) |
PMID | 29178678
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease |