HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.

Abstract
Liver cancer has become the second most deadly malignant disease, with no efficient targeted or immune therapeutic agents available yet. While dissecting the roles of cytoplasmic signaling molecules in hepatocarcinogenesis using an inducible mouse gene targeting system, Mx1-cre, we identified a potent liver tumor-inhibitory effect of synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), an inducer of the Mx1-cre system. Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis. The immunostimulatory dsRNA inhibited liver cancer initiation, apparently by boosting multiple anti-tumor activities of innate immunity, including induction of immunoregulatory cytokines, activation of NK cells and dendritic cells, and reprogramming of macrophage polarization. This study paves the way for the development of preventive and early interfering strategies for liver cancer to reduce the rapidly increasing incidences of liver cancer in an ever-growing population with chronic liver disorders.
AuthorsJin Lee, Rui Liao, Gaowei Wang, Bi-Huei Yang, Xiaolin Luo, Nissi M Varki, Shuang-Jian Qiu, Bing Ren, Wenxian Fu, Gen-Sheng Feng
JournalCell reports (Cell Rep) Vol. 21 Issue 7 Pg. 1870-1882 (Nov 14 2017) ISSN: 2211-1247 [Electronic] United States
PMID29141219 (Publication Type: Journal Article)
CopyrightCopyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Interferon Inducers
  • RNA, Double-Stranded
  • Poly I-C
Topics
  • Animals
  • Carcinogenesis (drug effects, immunology)
  • Dendritic Cells (immunology)
  • Immunity, Innate
  • Interferon Inducers (pharmacology, therapeutic use)
  • Killer Cells, Natural (immunology)
  • Liver Neoplasms (immunology, prevention & control)
  • Macrophage Activation
  • Macrophages (immunology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Poly I-C (pharmacology, therapeutic use)
  • RNA, Double-Stranded (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: