Double-Stranded RNA (RNA, Double Stranded)

RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.

Also Known As:

Networked: 1399 relevant articles (22 outcomes, 80 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matsumoto, Misako: 15 articles (04/2018 - 05/2002)
2.	Seya, Tsukasa: 15 articles (04/2018 - 05/2002)
3.	Akira, Shizuo: 11 articles (06/2013 - 09/2003)
4.	Imaizumi, Tadaatsu: 9 articles (01/2019 - 08/2004)
5.	Silverman, Robert H: 8 articles (01/2022 - 01/2003)
6.	Williams, Bryan R G: 8 articles (10/2012 - 01/2003)
7.	Dhar, Arti: 7 articles (09/2021 - 01/2017)
8.	Sen, Ganes C: 7 articles (01/2011 - 10/2003)
9.	Bhat, Audesh: 6 articles (09/2021 - 01/2017)
10.	Yoshida, Hidemi: 6 articles (01/2019 - 08/2004)

Related Diseases

1.	Virus Diseases (Viral Diseases) 01/01/2022 - "Our previous studies showed that chicken microRNA-155-5p (gga-miR-155-5p) enhanced IFN-β expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens. " 12/01/2013 - "To study the role of RIG-I in innate immunity, we used synthetic double-stranded RNA to mimic viral infection in vivo and detected duRIG-I transcripts in spleen and liver by quantitative real-time PCR (qRT-PCR). " 04/01/2013 - "In this study we investigated human mast cell response to double-stranded RNA and viral infection. " 09/01/2011 - "A mixed virus infection in a strain of the endophytic and entomopathogenic fungus Tolypocladium cylindrosporum was deduced from a study of the transmission to conidia of several double-stranded RNA (dsRNA) elements. " 05/01/2009 - "In the present study, we used double-stranded RNA (dsRNA), a viral replication intermediate, to mimic the acute phase of viral infection. "
2.	Infections 01/01/2020 - "Treatment of the Pacific oyster (Crassostrea gigas) with the double-stranded RNA analog poly(I·C) confers long-term protection against infection with ostreid herpesvirus 1, the causative agent of Pacific oyster mortality syndrome. " 01/01/2022 - "This study provides an implication for exploring the causes of reproductive disorders in mammals and humans caused by infection of double-stranded RNA virus." 01/01/2021 - "In this study, we sought to define the role of m6 A on infection by rice black streaked dwarf virus (RBSDV), a double-stranded RNA virus, of its vector small brown planthopper (SBPH). " 12/01/2019 - "The present study focuses on the modulation of intracellular RNAi during infection with rotavirus (RV), an enteric virus with double-stranded RNA genome. " 05/01/2012 - "In this study, we discovered that down-regulation of TICAM1, but not other components in this signaling pathway, occurred in a natural process of TLR3 activation induced by double-stranded RNA or human rhinovirus (RV) infection in airway epithelial cells and various other cell types. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2007 - "Our previous studies demonstrated that adenovirus-mediated overexpression of melanoma differentiation-associated gene-7 (Ad-mda7) leads to rapid induction of double-stranded RNA-dependent protein kinase (PKR) and activation of its downstream targets, resulting in apoptosis induction in human lung cancer cells. " 02/25/2015 - "Using lung cancer cell lines, A549 cells and DDP-resistant A549 cells (A549(DDP)), we determined the effect of sCLU silencing using short interfering double-stranded RNA (siRNA) on chemosensitivity in immunocompromised mice bearing A549(DDP) tumors. " 06/01/2014 - "Using lung cancer cell lines, A549 cells and DDP-resistant A549 cells (A549DDP), we determined the effect of sCLU silencing using short interfering double-stranded RNA (siRNA) on chemosensitivity in immunocompromised mice bearing A549DDP tumors. " 04/15/2002 - "Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR)." 10/01/2019 - "Scriptaid-mediated enhanced killing was eliminated in lung cancer cells that were engineered to express a protein which sequesters double stranded RNA. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/2019 - "Our previous study reported the safety and efficacy of EUS-guided fine-needle injection (EUS-FNI) of STNM01, a double-stranded RNA oligonucleotide that specifically represses CHST15, for use in patients with pancreatic cancer. " 04/01/2018 - "The aim of this study was to evaluate the safety and efficacy of EUS-guided fine-needle injection (EUS-FNI) of STNM01, the double-stranded RNA oligonucleotide that specifically represses CHST15, for use in patients with pancreatic cancer. " 01/01/2019 - "Herein, we investigated a therapeutic approach involving delivery of a short interfering double-stranded RNA (dsRNA), specific to Bcl2, with 5' triphosphate ends, by lipid calcium phosphate nanoparticles, in an orthotopic allograft KPC model of pancreatic cancer. "
5.	Neoplasms (Cancer) 12/15/2021 - "Oncolytic reovirus, which is a non-enveloped virus that contains 10-segmented double-stranded RNA genome, shows efficient tumor cell lysis without apparent cytotoxicity to normal cells and has been tested worldwide in clinical trials against various types of tumors. " 06/16/2017 - "Reovirus (Reolysin), a naturally occurring non-pathogenic, double-stranded RNA virus, has natural oncolytic activity and is being tested in phase I-III clinical trials in a variety of tumor types. " 08/03/2023 - "Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. " 01/01/2022 - "Many double-stranded RNA-binding domains (dsRBDs) interact with topologically distinct dsRNAs in biological pathways pivotal to viral replication, cancer causation, neurodegeneration, and so on. " 01/01/2021 - "Reovirus is a ubiquitous, non-pathogenic, double stranded RNA virus with anti-tumor properties. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Poly I-C
3.	Protein Kinases (Protein Kinase)
4.	Vaccines
5.	Oligonucleotides
6.	STNM01
7.	Phosphotransferases (Kinase)
8.	Hemagglutinins (Hemagglutinin)
9.	Interferons
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Injections
4.	Aftercare (After-Treatment)
5.	Radiotherapy