High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.

Abstract

Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A potential strategy is to target cardiac glucose metabolism at the early stages after ischemia when glycolysis is critical for myocyte survival. Building on our discovery that high-density lipoprotein (HDL) modulates skeletal muscle glucose metabolism, we now demonstrate that a single dose of reconstituted HDL (rHDL) delivered after myocardial ischemia increases cardiac glucose uptake, reduces infarct size, and improves cardiac remodeling in association with enhanced functional recovery in mice. These findings applied equally to metabolically normal and insulin-resistant mice. We further establish direct effects of HDL on cardiomyocyte glucose uptake, glycolysis, and glucose oxidation via the Akt signaling pathway within 15 min of reperfusion. These data support the use of infusible HDL preparations for management of acute coronary syndromes in the setting of primary percutaneous interventions.

• Authors: Sarah E Heywood, Adele L Richart, Darren C Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E Hagemeyer, Mark A Febbraio, Andrew L Siebel, Bronwyn A Kingwell
• Journal: Science translational medicine (Sci Transl Med) Vol. 9 Issue 411 (Oct 11 2017) ISSN: 1946-6242 [Electronic] United States
• PMID: 29021167 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Chemical References

• Lipoproteins, HDL
• Glucose

Topics

• Animals
• Glucose (metabolism)
• Lipoproteins, HDL (therapeutic use)
• Male
• Mice
• Mice, Inbred C57BL
• Myocardial Infarction (drug therapy)
• Myocardial Reperfusion Injury (drug therapy)
• Myocardium (metabolism, pathology)
• Signal Transduction (drug effects)