Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
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| Abstract |
It is recognized that IL-18 is related to development of asthma, but role of IL-18 in asthma remains controversial and confusing. This is largely due to lack of information on expression of IL-18 binding protein (BP) and IL-18 receptor (R) in asthma. In this study, we found that plasma levels of IL-18 and IL-18BP were elevated in asthma. The ratio between plasma concentrations of IL-18 and IL-18BP was 1:12.8 in asthma patients. We demonstrated that 13-fold more monocytes, 17.5-fold more neutrophils and 4.1-fold more B cells express IL-18BP than IL-18 in asthmatic blood, suggesting that there is excessive amount of IL-18BP to abolish actions of IL-18 in asthma. We also discovered that more IL-18R+ monocytes, neutrophils and B cells are located in asthmatic blood. Once injected, IL-18 eliminated IL-18R+ monocytes in blood, but up-regulated expression of IL-18R in lung macrophages of OVA-sensitized mice. Our data clearly indicate that the role of IL-18 in asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells. Therefore, IL-18R blocking or IL-18BP activity enhancing therapies may be useful for treatment of asthma.
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| Authors | Huiyun Zhang, Junling Wang, Ling Wang, Hua Xie, Liping Chen, Shaoheng He |
| Journal | Journal of cellular and molecular medicine (J Cell Mol Med) Vol. 22 Issue 1 Pg. 354-373 (01 2018) ISSN: 1582-4934 [Electronic] England |
| PMID | 28922563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. |
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