LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.

Abstract	Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
Authors	Xiang-Song Wu, Fang Wang, Huai-Feng Li, Yun-Ping Hu, Lin Jiang, Fei Zhang, Mao-Lan Li, Xu-An Wang, Yun-Peng Jin, Yi-Jian Zhang, Wei Lu, Wen-Guang Wu, Yi-Jun Shu, Hao Weng, Yang Cao, Run-Fa Bao, Hai-Bin Liang, Zheng Wang, Yi-Chi Zhang, Wei Gong, Lei Zheng, Shu-Han Sun, Ying-Bin Liu
Journal	EMBO reports (EMBO Rep) Vol. 18 Issue 10 Pg. 1837-1853 (10 2017) ISSN: 1469-3178 [Electronic] England
PMID	28887321 (Publication Type: Journal Article)
Copyright	© 2017 The Authors.
Chemical References	MIRN133 microRNA, human MIRN511 microRNA, human MicroRNAs RNA, Long Noncoding MTOR protein, human AKT1 protein, human Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases
Topics	Carcinogenesis (genetics) Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic Gallbladder (physiopathology) Gallbladder Neoplasms (genetics, pathology) Gene Expression Regulation, Neoplastic Humans MicroRNAs (genetics, metabolism) Neoplasm Metastasis Prognosis Proto-Oncogene Proteins c-akt (metabolism) RNA, Long Noncoding (genetics) TOR Serine-Threonine Kinases (metabolism)

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