Associations of Tumor Necrosis Factor-α and Interleukin-1β Levels and Polymorphisms with Post-Stroke Depression.

Abstract

OBJECTIVE:

Proinflammatory cytokines have been implicated in the pathophysiology of post-stroke depression (PSD), and their production levels are influenced by the transcriptional activity of genetic polymorphisms. The present study aimed to investigate the roles of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the serum on the risk of PSD while taking into account the TNF-α -850C/T and -308G/A polymorphisms and the IL-1β -511C/T and +3953C/T polymorphisms.

METHODS:

A total of 286 patients were evaluated at 2 weeks post stroke and 222 (78%) of these patients were followed up 1 year later. Depressive (major or minor) disorders were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria during both examinations; evaluations of cytokine concentrations and polymorphisms and demographic and clinical covariates were performed at 2 weeks. The effects of TNF-α and IL-1β concentrations and genotypes on PSD status were investigated using multivariate logistic regression models.

RESULTS:

Higher TNF-α levels were associated with PSD at 2 weeks in the presence of the -850T allele with a significant interaction term; higher IL-1β levels were associated with PSD at 2 weeks in the presence of the -511T allele with a borderline significant interaction term and with any +3953C/T polymorphism without a significant interaction term. No associations were found with PSD at 1 year.

CONCLUSIONS:

These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility.

• Authors: Jae-Min Kim, Hee-Ju Kang, Ju-Wan Kim, Kyung-Yeol Bae, Sung-Wan Kim, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho
• Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (Am J Geriatr Psychiatry) Vol. 25 Issue 12 Pg. 1300-1308 (Dec 2017) ISSN: 1545-7214 [Electronic] England
• PMID: 28844626 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• IL1B protein, human
• Interleukin-1beta
• TNF protein, human
• Tumor Necrosis Factor-alpha

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Depression (blood, etiology, genetics)
• Depressive Disorder, Major (blood, etiology, genetics)
• Female
• Follow-Up Studies
• Humans
• Interleukin-1beta (blood, genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Stroke (blood, complications)
• Tumor Necrosis Factor-alpha (blood, genetics)