Abstract | BACKGROUND: OBJECTIVE: METHODS: Ultrasonography assessed carotid artery plaque and common carotid intima-media thickness (cIMT) at baseline and after a median period of 9.4 years. Nuclear magnetic resonance spectroscopy estimated lipoprotein particle concentrations. Apolipoprotein B ( ApoB) and apolipoprotein A-I were measured using an automated immunoassay. Regression analysis determined associations of apolipoprotein and lipoprotein measurements with cIMT and relative risk regression determined associations with carotid plaque progression. RESULTS: After adjustment for typical CV risk factors, individuals in top quartiles of ApoB, ApoB/ apolipoprotein A-I, low-density lipoprotein particles ( LDL-P), small LDL-P, and total LDL-P/ high-density lipoprotein (HDL) particles showed similar risks of carotid plaque and cIMT progression as LDL-C, non- HDL cholesterol (HDL-C), total cholesterol (TC), and TC/HDL-C. A significant association with plaque progression remained in the top ApoB quartile after further adjustment for LDL-C (P = .02) or TC + HDL-C (P = .04), but was nonsignificant when adjusted for all lipid covariates (P = .086). Those in the top quartile of small LDL-P concentrations showed greater cIMT progression than those in the referent after adjustment for LDL-C, but this was nonsignificant after adjustment for TC + HDL-C. CONCLUSION:
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Authors | Brian T Steffen, Weihua Guan, Alan T Remaley, James H Stein, Mathew C Tattersall, Joel Kaufman, Michael Y Tsai |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2017 Sep - Oct
Vol. 11
Issue 5
Pg. 1181-1191.e1
ISSN: 1933-2874 [Print] United States |
PMID | 28826575
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoproteins B
- Cholesterol
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Topics |
- Apolipoproteins B
(blood)
- Carotid Artery Diseases
(blood, diagnostic imaging, ethnology, pathology)
- Carotid Intima-Media Thickness
- Cholesterol
(blood)
- Disease Progression
- Female
- Humans
- Male
- Middle Aged
- Plaque, Atherosclerotic
(blood, diagnostic imaging)
- Prospective Studies
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