Abstract | INTRODUCTION:
Pulmonary hypertension (PH) has been reported in hemodialysis patients, but data regarding its pathogenesis are scarce. This study aimed to evaluate the role of fluid overload in PH and its interrelationships with the usual biomarkers of micro-inflammatory state in hemodialysis patients. MATERIALS AND METHODS: In is a cross-sectional and prospective study, 119 consecutive hemodialysis patients at a Brazilian referral university hospital were evaluated between March 2007 and February 2013. Based on the presence of echocardiographic parameters of PH, patients were allocated to two groups of the PH group and the non-PH group. Clinical parameters, site and type of vascular access, bio-impedance, and laboratory findings were compared between the two groups and a logistic regression model was elaborated. RESULTS:
Pulmonary hypertension was found in 23 (19.0%) of 119 patients. The groups significantly differed in extracellular water, ventricular thickness, left atrium diameter, and ventricular filling. Additionally, laboratory data associated with PH were alpha-1-acid glycoprotein (140.0 ± 32.9 versus 116.0 ± 35.5; P < .001); C-reactive protein (median, 1.1 versus 1.6; P = .01) and B-type natriuretic peptide (median, 328 versus 77; P = .03). The adjusted logistic regression model, including alpha-1-acid glycoprotein and B-type natriuretic peptide, showed significant associations for both (odds ratio, 1.023; 95% confidence interval, 1.008 to 1.043; P = .004 and odds ratio, 3.074; 95% confidence interval, 1.49-6.35; P = .002, respectively). CONCLUSIONS:
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Authors | Hugo Hyung Bok Yoo, Roberto Dos Reis, Wagner Moneda Telini, Lidiane Rodrigues Telini, João Carlos Hueb, Silmeia Garcia Zanati Bazan, Pasqual Barretti, Luis Cuadrado Martin, Thais Thomaz Queluz |
Journal | Iranian journal of kidney diseases
(Iran J Kidney Dis)
Vol. 11
Issue 4
Pg. 303-308
(Jul 2017)
ISSN: 1735-8604 [Electronic] Iran |
PMID | 28794293
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Biomarkers
- Inflammation Mediators
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Topics |
- Adult
- Aged
- Arterial Pressure
- Biomarkers
(blood)
- Body Composition
- Brazil
- Cardiomegaly
(etiology)
- Chi-Square Distribution
- Cross-Sectional Studies
- Electric Impedance
- Female
- Hospitals, University
- Humans
- Hypertension, Pulmonary
(diagnosis, etiology, physiopathology)
- Inflammation
(blood, diagnosis, etiology)
- Inflammation Mediators
(blood)
- Kidney Failure, Chronic
(diagnosis, therapy)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Prospective Studies
- Pulmonary Artery
(physiopathology)
- Renal Dialysis
(adverse effects)
- Risk Factors
- Time Factors
- Treatment Outcome
- Water-Electrolyte Balance
- Water-Electrolyte Imbalance
(diagnosis, etiology, physiopathology)
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