Role of Forkhead Box Class O proteins in cancer progression and metastasis.

Abstract

It is now widely accepted that several gene alterations including transcription factors are critically involved in cancer progression and metastasis. Forkhead Box Class O proteins (FoxOs) including FoxO1/FKHR, FoxO3/FKHRL1, FoxO4/AFX and FoxO6 transcription factors are known to play key roles in proliferation, apoptosis, metastasis, cell metabolism, aging and cancer biology through their phosphorylation, ubiquitination, acetylation and methylation. Though FoxOs are proved to be mainly regulated by upstream phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3 K)/Akt signaling pathway, the role of FoxOs in cancer progression and metastasis still remains unclear so far. Thus, with previous experimental evidences, the present review discussed the role of FoxOs in association with metastasis related molecules including cannabinoid receptor 1 (CNR1), Cdc25A/Cdk2, Src, serum and glucocorticoid inducible kinases (SGKs), CXCR4, E-cadherin, annexin A8 (ANXA8), Zinc finger E-box-binding homeobox 2 (ZEB2), human epidermal growth factor receptor 2 (HER2) and mRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622, subsequently analyzed the molecular mechanism of some natural compounds targeting FoxOs and finally suggested future research directions in cancer progression and metastasis.

• Authors: Chang Geun Kim, Hyemin Lee, Nehal Gupta, Sharavan Ramachandran, Itishree Kaushik, Sangeeta Srivastava, Sung-Hoon Kim, Sanjay K Srivastava
• Journal: Seminars in cancer biology (Semin Cancer Biol) Vol. 50 Pg. 142-151 (06 2018) ISSN: 1096-3650 [Electronic] England
• PMID: 28774834 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Cell Cycle Proteins
• FOXO1 protein, human
• FOXO3 protein, human
• FOXO4 protein, human
• FOXO6 protein, human
• Forkhead Box Protein O1
• Forkhead Box Protein O3
• Forkhead Transcription Factors
• MicroRNAs
• Neoplasm Proteins
• Transcription Factors

Topics

• Cell Cycle Proteins
• Forkhead Box Protein O1 (genetics)
• Forkhead Box Protein O3 (genetics)
• Forkhead Transcription Factors (genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (genetics)
• Neoplasm Metastasis
• Neoplasm Proteins (genetics)
• Neoplasms (genetics, pathology)
• Transcription Factors (genetics)