Application of phytofilms based on biosolublepolymers is considered as a prospectivemethod for
burn treatment . Herbal remedies contain biologically active substances, that are relatively less toxic, do not cause skin irritation or
allergic reactions and, importantly, affectstrains of the microorganisms and viruses resistant to
antibiotics and
synthetic drugs. Nowadays, the advantages are given to such
burn healing drugs, which along with high specific efficacy, have
analgesic, anti-inflammatory and antimicrobial effects, and don't irritate the tissues. The mentioned peculiarities are characteristic for a new herbal phenolic
biopolymer poly[3-(3,4-dihydroxyphenyl)
glyceric acid](PDGA), isolated from the roots and stems of different comfrey species . The aim of the study was the development of the formulation and technology of biosoluble films for
burn treatment on the basis of PDGA. The optimal content of phytofilm for
burn healing was selected on the basis of the
biopharmaceutical study results. The impact of the film-former on the quality, adhesion and moisture absorption of the phytofilmhas been studied. The optimal degree of the phytofilm moisture, determining its high adhesive properties,was established. The film prepared on the basis of
sodium alginate, with 30.4% humidity, demonstrated the greatest adhesion strength. After investigation of the PDGA release it was found, that the hydrophilic bases such as:
sodium carboxymethyl-cellulose (69.2%) andsodium
alginate (78,65%) appeared to be optimal among the others. At the same time, taking into consideration the disadvantages of
sodium carboxymethyl-cellulose (tautening effect on burnt surface, relatively low stability), a film based on
sodium alginate has been chosen. The manufacturing technology for obtaining PDGA-containing phytofilm by casting is proposed. Theshelf-lifeofproposedPDGA-containingphytofilmis 2 years.