Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis.

Abstract

Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60-80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease.

• Authors: Isabel Rodriguez-Goncer, Rob Niven, David W Denning
• Journal: Medical mycology case reports (Med Mycol Case Rep) Vol. 16 Pg. 31-33 (Jun 2017) ISSN: 2211-7539 [Print] Netherlands
• PMID: 28652961 (Publication Type: Journal Article)