Flagellin FljB as an adjuvant to the recombinant adenovirus rabies glycoprotein vaccine increases immune responses against rabies in mice.

Abstract	Rabies virus (RABV) causes an acute progressive viral encephalitis. Although currently licensed vaccines have an excellent safety and efficacy record, the development of a safer and more cost-effective vaccine is still being sought. An E1-deleted, replication-defective human adenovirus type 5 (HAd5) vector expressing RABV glycoprotein (HAd5-G) is thought to be a promising candidate vaccine for immune prophylaxis against rabies. Salmonella enterica serovar Typhimurium (S. Typhimurium) flagellin is a well-known immune adjuvant. In this work, we have researched the adjuvant effect of flagellins (FljB and FliC) for HAd5 in mice for the first time. We found that the recombinant HAd5 expressing RABV glycoprotein and FljB (HAd5-GB), if administered intramuscularly, but not orally, could induce stronger immune responses and provide better protection against rabies than HAd5-G or the recombinant HAd5 expressing glycoprotein and FliC (HAd5-GC). These results suggest that the recombinant HAd5-GB has potential for development as a promising rabies vaccine.
Authors	Xingxing Xiao, Yun Zhang, Qiaolin Wei, Xiangping Yin
Journal	Archives of virology (Arch Virol) Vol. 162 Issue 9 Pg. 2655-2665 (Sep 2017) ISSN: 1432-8798 [Electronic] Austria
PMID	28550434 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Cytokines FljB protein, Salmonella Glycoproteins Peptide Fragments Rabies Vaccines Vaccines, Synthetic Viral Proteins rabies virus glycoprotein peptide Flagellin
Topics	Adenoviridae (genetics) Adjuvants, Immunologic Animals Cell Line Cricetinae Cytokines (genetics, metabolism) Female Flagellin (immunology) Gene Expression Regulation (immunology) Glycoproteins (immunology) Humans Mice Peptide Fragments (immunology) Rabies (prevention & control) Rabies Vaccines (immunology) Vaccines, Synthetic Viral Proteins (immunology)

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