Human interstitial cellular model in therapeutics of heart valve calcification.

Abstract

Calcific aortic valve disease is a common, severe heart condition that is currently with no proven, effective drug treatment and requires a surgical valve replacement or an entire heart explanation. Thus, developing novel, targeted therapeutic approaches becomes a major goal for cardiovascular disease research. To achieve this goal, isolated heart valve interstitial cells could be an advanced model to explore molecular mechanisms and measure drug efficacy. Based on this progress, molecular mechanisms that harbor components of  inflammation and fibrosis coupled with proteins, for example, BMP-2, TLRs, RANKL, Osteoprotegerin, have been proposed. Small molecules or antibodies targeting these proteins have shown promising efficacy for either reversing or slowing down calcification development in vitro. In this review, we summarize these potential therapeutics with some highlights of interstitial cellular models.

• Authors: Caimei He, Hai Tang, Zijian Mei, Nichujie Li, Zhi Zeng, Kwame Oteng Darko, Yulong Yin, Chien-An Andy Hu, Xiaoping Yang
• Journal: Amino acids (Amino Acids) Vol. 49 Issue 12 Pg. 1981-1997 (Dec 2017) ISSN: 1438-2199 [Electronic] Austria
• PMID: 28536843 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Pharmacological

Topics

• Animals
• Aortic Valve (cytology, pathology, physiopathology)
• Aortic Valve Stenosis (drug therapy, physiopathology)
• Biomarkers, Pharmacological (metabolism)
• Calcinosis (drug therapy, physiopathology)
• Drug Discovery
• Fibrosis (metabolism, physiopathology)
• Humans
• Inflammation (metabolism, physiopathology)
• Models, Biological
• Signal Transduction (physiology)