Abstract | BACKGROUND: METHODS: RESULTS: Preventive oral treatment with 0.1 mg/kg up to 3 mg/kg fingolimod once daily dissolved in rapeseed oil completely ameliorated clinical neuritis signs. It reduced circulating peripheral blood T cells and infiltrating T cells and macrophages in the sciatic nerve, whereas at the same time, it preserved blood-nerve barrier impermeability. Most importantly, fingolimod showed beneficial properties on the pathogenic process as indicated by fewer apoptotic Schwann cells and a lower amount of amyloid precursor protein indicative of axonal damage at the peak of disease course. CONCLUSIONS:
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Authors | Björn Ambrosius, Kalliopi Pitarokoili, Lisa Schrewe, Xiomara Pedreiturria, Jeremias Motte, Ralf Gold |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 14
Issue 1
Pg. 92
(04 26 2017)
ISSN: 1742-2094 [Electronic] England |
PMID | 28446186
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunosuppressive Agents
- Fingolimod Hydrochloride
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Topics |
- Animals
- Axons
(drug effects, immunology, pathology)
- Dose-Response Relationship, Drug
- Female
- Fingolimod Hydrochloride
(therapeutic use)
- Immunosuppressive Agents
(pharmacology, therapeutic use)
- Neuritis, Autoimmune, Experimental
(drug therapy, immunology, pathology)
- Neuroprotection
(drug effects, physiology)
- Rats
- Rats, Inbred Lew
- Schwann Cells
(drug effects, immunology, pathology)
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