Abstract | BACKGROUND: METHODS: We investigated the prevalence of these two DNA variants using specific restriction enzyme digest assays in 166 patients with Crohn disease, in 120 healthy first-degree relatives of Crohn disease patients, in 63 patients with ulcerative colitis and in 187 healthy individuals. RESULTS: The analysis revealed a frequency of 21.4% of the 2 genotypes for adult-type hypolactasia in our studied German cohort of healthy individuals, which is higher than previously reported (15%) based on the hydrogen (H₂) breath test. This might indicate a higher sensitivity of genotyping, but it has to be confirmed in larger cohorts. No significant difference was detectable in the frequency of the C/C_₁₃₉₁₀ and G/G_₂₂₀₁₈ genotypes in patients with Crohn Disease (C/C_₁₃₉₁₀: 21.7%; G/G_₂₂₀₁₈: 22.3%) compared to first-degree relatives (C/C_₁₃₉₁₀: 21.7%; G/G_₂₂₀₁₈: 20.8%), patients with ulcerative colitis (C/C_₁₃₉₁₀: 20.3%; G/G_₂₂₀₁₈: 20.3%) and healthy individuals (C/C_₁₃₉₁₀: 21.4%; G/G_₂₂₀₁₈: 21.4%). CONCLUSIONS:
|
Authors | C Büning, J Ockenga, S Krüger, J Jurga, P Baier, A Dignass, A Vogel, C Strassburg, R Weltrich, J Genschel, H Lochs, H Schmidt |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 38
Issue 5
Pg. 538-542
( 2003)
ISSN: 1502-7708 [Electronic] England |
PMID | 28443769
(Publication Type: Journal Article)
|