Abstract | AIM: METHOD: We conducted a case report and systematic literature review (up to 10 December 2016), focused on differences between herpes simplex encephalitis (HSE) and anti-NMDAR encephalitis phases, age-related characteristics of HSV-induced anti-NMDAR encephalitis, and therapy. For statistical analyses, McNemar's test, Fisher's test, and Wilcoxon rank sum test were used (two-tailed significance level set at 5%). RESULTS: Forty-three patients with biphasic disease were identified (31 children). Latency between HSE and anti-NMDAR encephalitis was significantly shorter in children than adults (median 24 vs 40.5d; p=0.006). Compared with HSE, anti-NMDAR encephalitis was characterized by significantly higher frequency of movement disorder (2.5% vs 75% respectively; p<0.001), and significantly lower rate of seizures (70% vs 30% respectively; p=0.001). Compared with adults, during anti-NMDAR encephalitis children had significantly more movement disorders (86.7% children vs 40% adults; p=0.006), fewer psychiatric symptoms (41.9% children vs 90.0% adults; p=0.025), and a slightly higher median modified Rankin Scale score (5 in children vs 4 in adults; p=0.015). During anti-NMDAR encephalitis, 84.6 per cent of patients received aciclovir (for ≤7d in 22.7%; long-term antivirals in 18.0% only), and 92.7 per cent immune therapy, but none had recurrence of HSE clinically or using cerebrospinal fluid HSV polymerase chain reaction (median follow-up 7mo). INTERPRETATION:
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Authors | Margherita Nosadini, Shekeeb S Mohammad, Francesco Corazza, Ezia Maria Ruga, Kavitha Kothur, Giorgio Perilongo, Anna Chiara Frigo, Irene Toldo, Russell C Dale, Stefano Sartori |
Journal | Developmental medicine and child neurology
(Dev Med Child Neurol)
Vol. 59
Issue 8
Pg. 796-805
(08 2017)
ISSN: 1469-8749 [Electronic] England |
PMID | 28439890
(Publication Type: Case Reports, Journal Article, Review, Systematic Review)
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Copyright | © 2017 Mac Keith Press. |
Topics |
- Adult
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis
(complications, etiology, microbiology, physiopathology)
- Child
- Encephalitis, Herpes Simplex
(complications, physiopathology)
- Female
- Humans
- Mental Disorders
(etiology, physiopathology)
- Movement Disorders
(etiology, physiopathology)
- Simplexvirus
(pathogenicity)
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