Blockade of β2-adrenoceptor, rather than β1-adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts.

Abstract

BACKGROUND:

Cardiac anaphylaxis is one of the features of anaphylactic hypotension. Patients treated with propranolol, a nonselective β-adrenoceptor (AR) antagonist, develop severe anaphylaxis, but the mechanism remains unknown. Under examination were the effects of β1- and β2-AR antagonist on anaphylaxis-induced coronary vasoconstriction and cardiac dysfunction in isolated blood-perfused rat hearts.

METHODS:

Isolated hearts from ovalbumin-sensitized Wistar rats were subjected to coronary perfusion with blood at a constant pressure and measurements were made of coronary blood flow and left ventricu-lar (LV) pressure. Following pretreatment with selective β2-AR antagonist ICI118,551 or selective β1-AR antagonist atenolol, cardiac anaphylaxis was induced by intracoronary injections of ovalbumin antigen. LV contractility was evaluated by the maximum increasing rate of systolic LV pressure (dP/dtmax).

RESULTS:

In response to antigen administrations, ICI118,551 pretreated hearts showed a greater de-crease in coronary blood flow and consequently a greater increase in coronary vascular resistance than the atenolol pretreated hearts. Pretreatment with ICI118,551 caused a greater decrease in dP/dtmax than those with atenolol.

CONCLUSIONS:

Cardiac anaphylaxis-induced contractile dysfunction and coronary spasm are severe in b2-, rather than β1-AR antagonist, pretreated isolated blood-perfused rat hearts.

• Authors: Yuhichi Kuda, Toshishige Shibamoto, Wei Yang, Tao Zhang, Mamoru Tanida, Yasutaka Kurata
• Journal: Cardiology journal (Cardiol J) Vol. 24 Issue 4 Pg. 403-408 ( 2017) ISSN: 1898-018X [Electronic] Poland
• PMID: 28353311 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrb1 protein, rat
• Adrenergic beta-1 Receptor Antagonists
• Adrenergic beta-2 Receptor Antagonists
• Propanolamines
• Receptors, Adrenergic, beta-1
• Receptors, Adrenergic, beta-2
• ICI 118551
• Atenolol
• Ovalbumin

Topics

• Adrenergic beta-1 Receptor Antagonists (toxicity)
• Adrenergic beta-2 Receptor Antagonists (toxicity)
• Anaphylaxis (chemically induced, metabolism, physiopathology)
• Animals
• Atenolol (toxicity)
• Coronary Vasospasm (chemically induced, metabolism, physiopathology)
• Coronary Vessels (drug effects, physiopathology)
• Disease Models, Animal
• Isolated Heart Preparation
• Male
• Myocardial Contraction (drug effects)
• Ovalbumin
• Propanolamines (toxicity)
• Rats, Wistar
• Receptors, Adrenergic, beta-1 (drug effects, metabolism)
• Receptors, Adrenergic, beta-2 (drug effects, metabolism)
• Time Factors
• Vasoconstriction (drug effects)
• Ventricular Dysfunction, Left (chemically induced, metabolism, physiopathology)
• Ventricular Function, Left (drug effects)
• Ventricular Pressure (drug effects)