Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma.

Abstract

Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-sialylated MUC1), which is a novel biliary marker, as a marker of HCC with hepatic progenitor cell (HPC)/biliary features and of prognosis. A total of 144 consecutive patients who underwent complete radiofrequency ablation of primary HCC were enrolled. A serum WFA-sialylated MUC1 level of 900 μL/mL was determined as the optimal cutoff value for prediction of immunohistochemical staining for HPC/biliary features [sialylated MUC1 and cytokeratin 19 (CK19)]. Positive staining rate of sialylated MUC1 and CK19 was significantly higher in patients with WFA-sialylated MUC1 ≥900 than those with WFA-sialylated MUC1 <900. Furthermore, cumulative incidence of HCC recurrence was significantly higher in patients with WFA-sialylated MUC1 ≥900 and on multivariate analysis, serum WFA-sialylated MUC1 levels was an independent predictor of HCC recurrence. These results revealed that serum WFA-sialylated MUC1 was associated with histological feature of HCC and recurrence after curative therapy and it could be a novel marker of HPC/biliary features in HCC and of prognosis.

• Authors: Nobuharu Tamaki, Atsushi Kuno, Atsushi Matsuda, Hanako Tsujikawa, Ken Yamazaki, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Masaaki Korenaga, Masashi Mizokami, Masayuki Kurosaki, Michiie Sakamoto, Hisashi Narimatsu, Namiki Izumi
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 244 (03 21 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 28325920 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Keratin-19
• Mucin-1
• Plant Lectins
• Receptors, N-Acetylglucosamine
• wisteria lectin

Topics

• Aged
• Biomarkers (blood)
• Carcinoma, Hepatocellular (diagnosis, pathology, therapy)
• Female
• Histocytochemistry
• Humans
• Keratin-19 (analysis)
• Liver (pathology)
• Male
• Middle Aged
• Mucin-1 (blood)
• Plant Lectins (blood)
• Prognosis
• Receptors, N-Acetylglucosamine (blood)
• Recurrence
• Serum (chemistry)