The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia.

Abstract

An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.

• Authors: Maurizio Bifulco, Simona Pisanti, Elena Ciaglia
• Journal: Endocrine (Endocrine) Vol. 58 Issue 1 Pg. 21-23 (Oct 2017) ISSN: 1559-0100 [Electronic] United States
• PMID: 28181143 (Publication Type: Journal Article, Review)

Chemical References

• Cholesterol
• Glucose
• Mevalonic Acid

Topics

• Animals
• Cholesterol (metabolism)
• Glucose (metabolism)
• Hepatocytes (immunology, metabolism)
• Humans
• Hyperglycemia (immunology, metabolism, pathology)
• Inflammation (immunology, pathology)
• Metabolic Networks and Pathways
• Mevalonic Acid (metabolism)