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Renoprotective Effects of Shout Camphor Medicinal Mushroom (Taiwanofungus camphorates, Basidiomycetes) Mycelia on Several Media in Mice with Chronic Kidney Disease.

Abstract
Taiwanofungus camphoratus has been widely used in Taiwan as a folk medicine to prevent and treat liver diseases, diarrhea, abdominal pain, itchy skin, and hypertension. Recent studies have shown that T. camphoratus mycelia extracts exert anti-inflammatory and antioxidant effects on some types of renal disease, but the effect of T. camphoratus mycelia on chronic kidney disease (CKD) remains unclear. In this study we used the Bioresource Collection and Research Center (BCRC) medium and modified media (e.g., BCRC+A, HKS1, and HKS1+A media) to incubate T. camphorates mycelia and detect the feasible benefits of renal protection in mice with CKD. Five groups of mice with a partial nephrectomy (each mouse weighed approximately 30 g) received a daily administration of different media-treated T. camphoratus mycelia water solutions (3 mg dried mycelia dissolved in 0.3 mL water) by oral gavage for 30 days, while a control group received distilled water. The results show that progressive increased blood urea nitrogen and serum creatinine were significantly inhibited in the HKS1+A group on days 10 and 30. Plasma total protein was effectively increased in the HKS1 and HKS1+A groups. The BCRC and BCRC+A groups exhibited no obvious improvement in renal function. The results suggest that the HKS1+A medium provides the optimal effect in preventing the deterioration of kidney function and might have a renoprotective effect on CKD.
AuthorsShu-Chi Wang, Chih-Hui Yang, Alexandru Mihai Grumezescu, Yu-Mei Lin, Keng-Shiang Huang, Wei-Ting Wang, Hsin-Yi Su, Cing-Yan Jhang, Ruo-Yun Chung, Jiun-Hua Chou
JournalInternational journal of medicinal mushrooms (Int J Med Mushrooms) Vol. 18 Issue 12 Pg. 1105-1114 ( 2016) ISSN: 1940-4344 [Electronic] United States
PMID28094748 (Publication Type: Journal Article)
Chemical References
  • Urea
  • Creatinine
Topics
  • Administration, Oral
  • Animals
  • Biological Therapy (methods)
  • Coriolaceae
  • Creatinine (blood)
  • Diet (methods)
  • Disease Models, Animal
  • Male
  • Mice, Inbred ICR
  • Renal Insufficiency, Chronic (therapy)
  • Treatment Outcome
  • Urea (blood)

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