Abstract | OBJECTIVE: SUMMARY BACKGROUND DATA: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion. METHODS: RESULTS: CONCLUSIONS:
Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.
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Authors | Richard S Hoehn, Peter L Jernigan, Lukasz Japtok, Alex L Chang, Emily F Midura, Charles C Caldwell, Burkhard Kleuser, Alex B Lentsch, Michael J Edwards, Erich Gulbins, Timothy A Pritts |
Journal | Annals of surgery
(Ann Surg)
Vol. 265
Issue 1
Pg. 218-226
(01 2017)
ISSN: 1528-1140 [Electronic] United States |
PMID | 28009749
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Enzyme Inhibitors
- Amitriptyline
- Sphingomyelin Phosphodiesterase
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Topics |
- Amitriptyline
(pharmacology)
- Animals
- Biomarkers
(metabolism)
- Blood Preservation
(adverse effects, methods)
- Cell-Derived Microparticles
(metabolism)
- Enzyme Inhibitors
(pharmacology)
- Erythrocyte Transfusion
(adverse effects)
- Erythrocytes
(drug effects, enzymology)
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Pneumonia
(etiology, metabolism, pathology, prevention & control)
- Sphingomyelin Phosphodiesterase
(antagonists & inhibitors, deficiency)
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