Abstract | BACKGROUND AND OBJECTIVES: MATERIALS AND METHODS: RESULTS: Although the response was variable in treated patients, cessation of bleeding was observed within 12 h in all such affected patients (n = 7), even in patients with platelet counts that were not increased (n = 3). Furthermore, platelet counts were observed to increase already within 1 h in 10 (53%) patients and within 8 h in 12 (63%) patients. CONCLUSIONS: From a clinical perspective, the onset of therapeutic effects of intravenous immunoglobulin in patients with ITP may occur at an earlier stage and be superior to that previously expected. Failure to measure an increase in platelets in the circulation of 'non-responders' may be explained by an increased consumption of platelets due to recognizable or unrecognizable bleeding in such affected patients.
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Authors | B Mayer, F Depré, F Ringel, A Salama |
Journal | Vox sanguinis
(Vox Sang)
Vol. 112
Issue 1
Pg. 64-69
(Jan 2017)
ISSN: 1423-0410 [Electronic] England |
PMID | 28001314
(Publication Type: Journal Article)
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Copyright | © 2016 International Society of Blood Transfusion. |
Chemical References |
- Immunoglobulins, Intravenous
|
Topics |
- Adult
- Aged
- Blood Platelets
(cytology, drug effects)
- Chronic Disease
- Female
- Hemorrhage
(prevention & control)
- Humans
- Immunoglobulins, Intravenous
(administration & dosage)
- Kinetics
- Male
- Middle Aged
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(therapy)
- Risk
- Young Adult
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