Abstract |
miRNA-221 is one of the over 700 kinds of currently known microRNAs ( miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para- carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis.
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Authors | Fan Chen, Xin-Feng Li, Dong-Sheng Fu, Jian-Guo Huang, Shun-E Yang |
Journal | Cancer biomarkers : section A of Disease markers
(Cancer Biomark)
Vol. 18
Issue 2
Pg. 209-214
( 2017)
ISSN: 1875-8592 [Electronic] Netherlands |
PMID | 27983537
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- MIRN221 microRNA, human
- MicroRNAs
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Topics |
- Adult
- Biomarkers, Tumor
(genetics)
- Carcinoma, Hepatocellular
(genetics, mortality, pathology)
- Disease-Free Survival
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Kaplan-Meier Estimate
- Liver Neoplasms
(genetics, mortality, pathology)
- Male
- MicroRNAs
(genetics)
- Middle Aged
- Prognosis
- Real-Time Polymerase Chain Reaction
(methods)
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