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Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma.

Abstract
miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis.
AuthorsFan Chen, Xin-Feng Li, Dong-Sheng Fu, Jian-Guo Huang, Shun-E Yang
JournalCancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 18 Issue 2 Pg. 209-214 ( 2017) ISSN: 1875-8592 [Electronic] Netherlands
PMID27983537 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • MIRN221 microRNA, human
  • MicroRNAs
Topics
  • Adult
  • Biomarkers, Tumor (genetics)
  • Carcinoma, Hepatocellular (genetics, mortality, pathology)
  • Disease-Free Survival
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kaplan-Meier Estimate
  • Liver Neoplasms (genetics, mortality, pathology)
  • Male
  • MicroRNAs (genetics)
  • Middle Aged
  • Prognosis
  • Real-Time Polymerase Chain Reaction (methods)

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