Objective: To evaluate the efficacy of large spot indirect ophthalmoscopy
laser alone or combined with systemic
chemotherapy in the treatment of early and middle stage
retinoblastoma. Methods: Retrospective series case study. Clinical data of 21 patients (22 eyes) who were diagnosed as
retinoblastoma (RB) in Peking University People's Hospital from March 2009 to August 2014 were collected. Medical and family history, ocular ultrasound, orbital and cranial MRI or CT examination of RB Children were detailed recorded. Ocular examination and
laser treatment were performed under
general anesthesia, once every 3-4 weeks until the
tumor was under control. The observation period was at least 3 months after the last treatment. The ocular examination included intraocular pressure measurement, anterior segment and fundus examination and the fundus photography with Retcam.
Laser therapeutic instrument was large spot indirect ophthalmoscopy
laser of 810nm wavelength. Results: Of the 21 children, 16 were male and 5 were female. The range of age was 3 to 82 months averaged 17.3 months. Among 22 eyes, four with small
tumor, eight with medium
tumor, and ten with large
tumor. Two eyes underwent
laser treatment only and 20 eyes underwent
laser treatment combined with systemic
chemotherapy. During the average observation period of 33.9 months, 15
tumors were treated successfully, but 7 failed. The total success rate was 68.2%. The number and success rate of small, medium and large
tumor eyes were 4 (100%), 5 (62.5%) and 5 (50%), respectively. There was one case of
tumor brain metastases, and the classification of contralateral eye of the child was E phase.
COMPLICATIONS: