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Germline miRNA DNA variants and the risk of colorectal cancer by subtype.

Abstract
MicroRNAs (miRNAs) regulate up to one-third of all protein-coding genes including genes relevant to cancer. Variants within miRNAs have been reported to be associated with prognosis, survival, response to chemotherapy across cancer types, in vitro parameters of cell growth, and altered risks for development of cancer. Five miRNA variants have been reported to be associated with risk for development of colorectal cancer (CRC). In this study, we evaluated germline genetic variation in 1,123 miRNAs in 899 individuals with CRCs categorized by clinical subtypes and in 204 controls. The role of common miRNA variation in CRC was investigated using single variant and miRNA-level association tests. Twenty-nine miRNAs and 30 variants exhibited some marginal association with CRC in at least one subtype of CRC. Previously reported associations were not confirmed (n = 4) or could not be evaluated (n = 1). The variants noted for the CRCs with deficient mismatch repair showed little overlap with the variants noted for CRCs with proficient mismatch repair, consistent with our evolving understanding of the distinct biology underlying these two groups. © 2016 The Authors Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.
AuthorsNoralane M Lindor, Melissa C Larson, Melissa S DeRycke, Shannon K McDonnell, Saurabh Baheti, Zachary C Fogarty, Aung Ko Win, John D Potter, Daniel D Buchanan, Mark Clendenning, Polly A Newcomb, Graham Casey, Steven Gallinger, Loïc Le Marchand, John L Hopper, Mark A Jenkins, Ellen L Goode, Stephen N Thibodeau
JournalGenes, chromosomes & cancer (Genes Chromosomes Cancer) Vol. 56 Issue 3 Pg. 177-184 (03 2017) ISSN: 1098-2264 [Electronic] United States
PMID27636879 (Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural)
Copyright© 2016 The Authors Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.
Chemical References
  • Biomarkers, Tumor
  • MicroRNAs
Topics
  • Biomarkers, Tumor (genetics)
  • Case-Control Studies
  • Colorectal Neoplasms (genetics)
  • Follow-Up Studies
  • Genetic Variation (genetics)
  • Germ-Line Mutation (genetics)
  • Humans
  • MicroRNAs (genetics)
  • Neoplasm Staging
  • Prognosis
  • Risk Factors

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