Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs.

Abstract

The effect of overexpression of Oct-1 protein isoforms on the cell response to two anticancer drugs camptothecin and dexamethasone was studied. The effect of Oct-1 isoforms on regulated gene transcription was estimated by the difference in the level of mRNA in Burkitt's lymphoma cells (Namalwa line) untransfected and stably transfected with Oct-1 isoforms. The response to anticancer drugs of the Oct-1 target genes involved in the development of apoptosis depended, firstly, on the type of drug, secondly, on the concentration of Oct-1 in cells. and, thirdly, on the Oct-1 isoform with which these cells were transfected.

• Authors: T N Portseva, E V Pankratova, A G Stepchenko, S G Georgieva
• Journal: Doklady. Biochemistry and biophysics (Dokl Biochem Biophys) Vol. 469 Issue 1 Pg. 269-72 (Jul 2016) ISSN: 1608-3091 [Electronic] United States
• PMID: 27599509 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biomarkers, Tumor
• MYC protein, human
• Octamer Transcription Factor-1
• POU2F1 protein, human
• Protein Isoforms
• Proto-Oncogene Proteins c-myc
• RNA, Messenger
• Dexamethasone
• Camptothecin

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects, physiology)
• Biomarkers, Tumor (genetics, metabolism)
• Burkitt Lymphoma (drug therapy, genetics, metabolism)
• Camptothecin (pharmacology)
• Cell Line, Tumor
• Dexamethasone (pharmacology)
• Gene Expression Regulation, Neoplastic (drug effects, physiology)
• Humans
• Octamer Transcription Factor-1 (genetics, metabolism)
• Protein Isoforms
• Proto-Oncogene Proteins c-myc (genetics, metabolism)
• RNA, Messenger (metabolism)
• Transfection