Camptothecin

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Also Known As:

Networked: 2033 relevant articles (126 outcomes, 298 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pommier, Yves: 45 articles (01/2022 - 02/2002)
2.	Pisano, Claudio: 11 articles (10/2013 - 12/2002)
3.	Zunino, Franco: 11 articles (07/2012 - 12/2002)
4.	Davis, Mark E: 10 articles (01/2020 - 05/2004)
5.	Abnous, Khalil: 8 articles (01/2022 - 03/2017)
6.	Alibolandi, Mona: 8 articles (01/2022 - 03/2017)
7.	Ramezani, Mohammad: 8 articles (01/2022 - 03/2017)
8.	Taghdisi, Seyed Mohammad: 8 articles (01/2022 - 03/2017)
9.	Song, Joon Myong: 8 articles (01/2022 - 09/2007)
10.	Zhang, Wei: 8 articles (10/2021 - 07/2011)

Related Diseases

1.	Neoplasms (Cancer) 10/12/2023 - "Head-to-head comparison to Enhertu, an approved camptothecin-based ADC, revealed improved target-mediated killing of tumor cells, excellent bystander killing, drastically improved linker stability in vitro and in vivo and superior in vivo efficacy over four tested dose levels in a xenograft model. " 09/05/2022 - "7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. " 11/07/2017 - "Camptothecin is a novel NRF2 inhibitor that may be repurposed in combination with other chemotherapeutics to enhance their efficacy in treating high NRF2-expressing cancers." 11/15/1991 - "In order to understand the high efficacy of camptothecin derivatives against human colon tumor xenografts in nude mice, we have studied the transport properties of camptothecin derivatives across cellular membranes of MDR1-overexpressing cells. " 08/01/2017 - "Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs. "
2.	Colonic Neoplasms (Colon Cancer) 01/01/2021 - "Fabrication of versatile targeted lipopolymersomes for improved camptothecin efficacy against colon adenocarcinoma in vitro and in vivo." 09/06/2021 - "Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells." 01/01/2021 - "In this work, 27 camptothecin derivatives were synthesized and screened for their cytotoxicity against A549 (lung) and HCT-116 (colon) cancer cell lines. " 09/01/2020 - "Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38." 05/14/2020 - "Herein, we utilized the colon cancer cell lines, Caco2 and DLD1, to investigate heterogeneity of topoisomerase 1 (TOP1) activity in different cell subpopulations, and the consequences for the chemotherapeutic response towards the TOP1 targeting drug, camptothecin. "
3.	Breast Neoplasms (Breast Cancer) 11/01/2017 - "Recently we reported formulation of camptothecin microemulsions with increased solubility for the improved treatment of breast cancer. " 01/01/1993 - "Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts." 08/01/2020 - "In this study, we investigated the anticancer effects of a novel camptothecin derivative, CPT211, against human breast cancer. " 04/01/2006 - "The purpose of this phase II study was to evaluate the efficacy and tolerability of Orathecin, an oral camptothecin analog that has exhibited antitumor activity in breast cancer patients during preclinical studies. " 08/01/2022 - "The rate of release of the encapsulated camptothecin and anticancer effects on breast cancer cells are investigated. "
4.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2021 - "Therapeutic efficacy and gastrointestinal biodistribution of polycationic nanoparticles for oral camptothecin delivery in early and late-stage colorectal tumor-bearing animal model." 03/01/2003 - "Therefore, the present study was designed to investigate the effect of adenovirus-mediated E2F-1 gene transfer on chemosensitivity of colorectal cancer to camptothecin, in vitro and in vivo. " 06/06/2023 - "Interestingly, Icacinaceae is considered a potential alternative resource for camptothecin and its derivatives, which are used in treating ovarian and metastatic colorectal cancer. " 12/30/2022 - "Anti-Colorectal Cancer Effects of a Novel Camptothecin Derivative PCC0208037 In Vitro and In Vivo." 10/15/2018 - "Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo."
5.	Carcinoma (Carcinomatosis) 11/01/2018 - "Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative." 03/01/2015 - "Encapsulation in PLGA-PEG enhances 9- nitro-camptothecin cytotoxicity to human ovarian carcinoma cell line through apoptosis pathway." 06/28/2010 - "Following treatment with the camptothecin or ionizing radiation, both inducing double-strand DNA breaks, the ovarian carcinoma A2780 cells exhibited activation of the ATM-Chk2 pathway and early induction of apoptosis. " 08/01/2007 - "After a short dose of camptothecin in human colon carcinoma HT29 cells, DNA replication was inhibited rapidly and did not recover for several hours following drug removal. " 05/11/2006 - "In human colon carcinoma HCT116 cells with wild-type (wt) p53, gammaH2AX reverses after camptothecin removal. "

Related Drugs and Biologics

1.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole
2.	Irinotecan (Camptosar)
3.	Topoisomerase I Inhibitors
4.	Topotecan (Hycamtin)
5.	Type I DNA Topoisomerases (Topoisomerase I)
6.	Cisplatin (Platino)
7.	Cyclodextrins
8.	Polymers
9.	Prodrugs
10.	IT-101

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Aftercare (After-Treatment)
5.	Microspheres (Microsphere)