Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer.

Abstract

One of complications associated with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is peptic ulcer. Recently, we found that orally administered phosphatidic acid (PA) ameliorated aspirin-induced stomach lesions in mice. In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer. Among examined, buckwheat (Fagopyrum esculentum) bran contained the highest level of PA (188 mg/100 g). PA was the richest phospholipid (25%) in the lipid fraction of the buckwheat bran. Administration of the lipid extracts of buckwheat bran significantly ameliorated indomethacin-induced stomach lesions in mice. In contrast, wheat (Triticum durum) bran lipids (PA, 4%) and soybean (Glycine max) lipids (PA, 3%) were not associated with ameliorative effects. These results indicated that PA-rich lipids can be used as an effective supplement for prevention of NSAID-induced stomach ulcer.

• Authors: Sheuli Afroz, Teru Ikoma, Ayano Yagi, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 64 Issue 37 Pg. 6950-7 (Sep 21 2016) ISSN: 1520-5118 [Electronic] United States
• PMID: 27561232 (Publication Type: Journal Article)

Chemical References

• Phosphatidic Acids
• Plant Extracts
• Protective Agents
• Indomethacin

Topics

• Animals
• Edible Grain (chemistry)
• Fagopyrum (chemistry)
• Gastric Mucosa (drug effects)
• Humans
• Indomethacin (adverse effects)
• Male
• Mice
• Mice, Inbred ICR
• Phosphatidic Acids (administration & dosage)
• Plant Extracts (administration & dosage)
• Protective Agents (administration & dosage)
• Seeds (chemistry)
• Glycine max (chemistry)
• Stomach Ulcer (chemically induced, prevention & control)
• Triticum (chemistry)