Phosphatidic Acids (Phosphatidic Acid)

Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.

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Networked: 240 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Murakami-Murofushi, Kimiko: 12 articles (09/2015 - 06/2003)
2.	Tsukahara, Tamotsu: 6 articles (09/2015 - 11/2010)
3.	Gotoh, Mari: 5 articles (10/2014 - 12/2010)
4.	Murofushi, Hiromu: 5 articles (01/2014 - 08/2006)
5.	Min, Do Sik: 5 articles (09/2011 - 01/2007)
6.	Gomez-Cambronero, Julian: 4 articles (09/2015 - 04/2013)
7.	Kobayashi, Susumu: 4 articles (01/2007 - 06/2003)
8.	Matsuda, Yoshikazu: 3 articles (09/2015 - 01/2013)
9.	Tsukahara, Ryoko: 3 articles (09/2015 - 08/2006)
10.	Haniu, Hisao: 3 articles (09/2015 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 10/15/1992 - "This system has been used to study the proposed role phospholipid metabolites, particularly phosphatidic acid (PA), may play (Kaszkin et al., Cancer Res., 51: 4328-4335, 1991) in the extracellular control of cells at the physiological restriction site in G2 phase. " 10/14/2014 - "The phosphatidic acid formed will maintain a cancer phenotype through the regulation of mTOR. " 01/01/2013 - "Intriguingly, cyclic phosphatidic acid (cPA) and its structural analogs inhibit growth in many cancer cell lines, and our previous work has suggested that cPA increases cAMP production. " 09/01/2009 - "Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells." 10/01/2004 - "By contrast, in platelets and some cancer cells, LPA is converted from phosphatidic acid. "
2.	Neoplasm Metastasis (Metastasis) 10/29/2010 - "In addition to LPA formation, later ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. " 01/01/2008 - "On the other hand, cyclic phosphatidic acids (naturally occurring analogs of LPA generated by ATX) have anti-proliferative activity and inhibit tumor cell invasion and metastasis. " 01/01/2007 - "Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid." 08/11/2006 - "Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis." 06/01/2003 - "Moreover, we reported that palmitoyl-cyclic phosphatidic acid (Pal-cPA), a structural analogue of LPA, inhibits LPA-induced migration of MM1 cells and experimental metastasis of B16 murine melanoma cells. "
3.	Autolysis 03/01/1980 - "At the same time, an increase in lysophosphatides within 4 hr of autolysis and a decrease in concentration of phosphatidic acids within 24 hrs were found in the control group. " 03/01/1980 - "In animals with hypoxia phosphatidic acids were only slightly increased and polyglycerophosphatides were found during subsequent periods of autolysis." 09/01/1994 - "Relative content of phosphatidyl serines + sphingomyelins, phosphatidic acids + polyglycerophosphatides in grey substance as well as of phosphatidylinositides, phosphatidic acids + polyglycerophosphatides in white substance were increased, while phosphatidylinosidtides in grey substance and phosphatidyl serines + sphingomyelins in white substance were decreased within later (4 and 24 hrs) periods of autolysis. " 03/01/2004 - "The development of autolysis in grey brain matter of albino rats was accompanied by desintegration of aminophospholipids with parallel increase of glycerophosphates (GLP) and phosphatidic acids (PA) on early stages of incubation and lysophospholipids (LPL) on later stages. " 04/16/1996 - "Phosphatidyl inositol, phosphatidyl choline, phosphatidyl glycerol, phosphatidyl serine, phosphatidyl ethanolamine, phosphatidic acid and sphingomyelin were all found to be effective at reducing the Ca2+ requirement for m-calpain autolysis. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2001 - "We previously demonstrated that phosphatidic acid (PA) induces chemotactic migration of highly metastatic breast cancer cells MDA-MB-231. " 02/16/2000 - "Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid." 02/16/2000 - "Since an enhanced ability to migrate heightens the metastatic potential of cells within solid tumors, our results suggest that the metastatic capabilities of breast cancer cells may be enhanced by a receptor-driven cellular process initiated by phosphatidic acid or related lipid phosphate messengers." 02/01/2013 - "In the present study, lipidomic analysis has been extended to human mammary epithelial cells and breast cancer cell lines (MCF10A, T47-D, and MDA-MB-231), using TLC-MS, validated by hydrophilic interaction liquid chromatography-MS. Differences in phosphatidylethanolamine (PE) content relative to total amount of PLs was highest in non-malignant cells while phosphatidic acid was present with highest relative abundance in metastatic cells. " 09/01/2001 - "Steady state fluorescence spectroscopy is used to study the binding characteristics of zinc phthalocyanine (ZnPc) to MCF-7 human breast cancer cells solubilized in a liposomal vesicle prepared with L-alpha-phosphatidic acid, dipalmitoyl. "
5.	Insulin Resistance 01/01/2015 - "In line with this, recent studies have revealed that insulin resistance is driven by the accumulation of phosphatidic acid and diacylglycerol in hepatocytes and that cholesterol-overloaded stellate cells are associated with fibrosis in the liver. " 02/21/2014 - "In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). " 02/06/2015 - "The data support roles for intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesis: diacylglycerol (DAG), which may cause insulin resistance in liver by activating PKCϵ, and phosphatidic acid (PA), which inhibits insulin action in hepatocytes by disrupting the assembly of mTOR and rictor. "

Related Drugs and Biologics

1.	Phosphatidylinositols (Phosphatidylinositol)
2.	Serine (L-Serine)
3.	Ethanolamine (Colamine)
4.	Choline (Choline Chloride)
5.	Phosphatidylglycerols
6.	Bombesin
7.	m-calpain
8.	Phosphatidylcholines (Phosphatidylcholine)
9.	lysophosphatidic acid (MOPA)
10.	Cholesterol

Related Therapies and Procedures

1.	Topical Administration
2.	Heterologous Transplantation (Xenotransplantation)
3.	Injections
4.	Intravenous Infusions
5.	Fluid Therapy (Oral Rehydration Therapy)