Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.
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| Abstract |
Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD.
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| Authors | Sun Young Choi, Chang Taek Oh, Tae-Rin Kwon, Hyun Jung Kwon, Eun Ja Choi, Yu-Jin Jang, Hye Sung Kim, Hong Chu, Seog Kyun Mun, Myeung Nam Kim, Beom Joon Kim |
| Journal | Lasers in medical science (Lasers Med Sci) Vol. 31 Issue 7 Pg. 1437-45 (Sep 2016) ISSN: 1435-604X [Electronic] England |
| PMID | 27394442 (Publication Type: Journal Article) |
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