First-Generation Versus Second-Generation Drug-Eluting Stents in Coronary Chronic Total Occlusions: Two-Year Results of a Multicenter Registry.

Abstract

BACKGROUND:

Limited data are available regarding the long-term clinical outcomes of second-generation drug-eluting stents (DES) versus first-generation DES in patients with coronary chronic total occlusion (CTO) who undergo percutaneous coronary intervention (PCI). The aim of this study was to compare the clinical outcomes of second-generation DES with those of first-generation DES for the treatment of CTO.

METHODS AND RESULTS:

Between March 2003 and February 2012, 1,006 consecutive patients with CTO who underwent successful PCI using either first-generation DES (n = 557) or second-generation DES (n = 449) were enrolled in a multicenter, observational registry. Propensity-score matching was also performed. The primary outcome was cardiac death over a 2-year follow-up period. No significant differences were observed between the two groups regarding the incidence of cardiac death (first-generation DES versus second-generation DES; 2.5% vs 2.0%; hazard ratio [HR]: 0.86; 95% confidence interval [CI]: 0.37 to 1.98; p = 0.72) or major adverse cardiac events (MACE, 11.8% vs 11.4%; HR: 1.00; 95% CI: 0.67 to 1.50; p = 0.99). After propensity score matching, the incidences of cardiac death (HR: 0.86; 95% CI: 0.35 to 2.06; p = 0.86) and MACE (HR: 0.93; 95% CI: 0.63 to 1.37; p = 0.71) were still similar in both groups. Furthermore, no significant differences were observed between sirolimus-eluting, paclitaxel-eluting, zotarolimus-eluting, and everolimus-eluting stents regarding the incidence of cardiac death or MACE.

CONCLUSION:

This study shows that the efficacy of second-generation DES is comparable to that of first-generation DES for treatment of CTO over 2 years of follow-up.

• Authors: Jong-Hwa Ahn, Jeong Hoon Yang, Cheol Woong Yu, Je Sang Kim, Hyun Jong Lee, Rak Kyeong Choi, Tae Hoon Kim, Ho Joon Jang, Young Jin Choi, Young Moo Roh, Won-Heum Shim, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
• Journal: PloS one (PLoS One) Vol. 11 Issue 6 Pg. e0157549 ( 2016) ISSN: 1932-6203 [Electronic] United States
• PMID: 27314589 (Publication Type: Journal Article)

Topics

• Aged
• Angioplasty, Balloon, Coronary
• Coronary Angiography
• Coronary Occlusion (drug therapy, epidemiology, physiopathology)
• Death
• Drug-Eluting Stents
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Myocardial Infarction (drug therapy, epidemiology, physiopathology)
• Percutaneous Coronary Intervention (methods)
• Treatment Outcome