Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus.

Abstract

Tedizolid, a novel oxazolidinone, exhibits bacteriostatic activity through inhibition of protein synthesis. The efficacies of tedizolid, linezolid, and vancomycin were compared in a murine catheter-related biofilm infection caused by methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA, respectively) strains engineered for bioluminescence. We observed significantly improved efficacy in terms of decreased S. aureus densities and bioluminescent signals in the tedizolid-treated group versus the linezolid- and vancomycin-treated groups in the model of infection caused by the MSSA and MRSA strains.

• Authors: Arnold S Bayer, Wessam Abdelhady, Liang Li, Rachelle Gonzales, Yan Q Xiong
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 60 Issue 8 Pg. 5092-6 (08 2016) ISSN: 1098-6596 [Electronic] United States
• PMID: 27297485 (Publication Type: Journal Article)
• Copyright: Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Chemical References

• Anti-Bacterial Agents
• Organophosphates
• Oxazoles
• Vancomycin
• Linezolid
• tedizolid phosphate
• Methicillin

Topics

• Animals
• Anti-Bacterial Agents (therapeutic use)
• Biofilms (drug effects)
• Catheter-Related Infections (drug therapy, microbiology)
• Linezolid (therapeutic use)
• Methicillin (therapeutic use)
• Methicillin-Resistant Staphylococcus aureus (drug effects, pathogenicity)
• Mice
• Organophosphates (therapeutic use)
• Oxazoles (therapeutic use)
• Staphylococcus aureus (drug effects, pathogenicity)
• Vancomycin (therapeutic use)