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Methicillin (Metin)

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One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Also Known As:

Metin; Methicillin Sodium; Staphcillin; CSL Brand of Methicillin Sodium; Methicillin Hydrate, Monosodium Salt; Methicillin Monohydrate, Monosodium Salt; Meticillin; Dimethoxyphenyl Penicillin; Penicillin, Dimethoxyphenyl; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-

Networked: 1681 relevant articles (105 outcomes, 124 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Mason, Edward O: 16 articles (04/2015 - 10/2002)
2.	Kaplan, Sheldon L: 16 articles (04/2015 - 10/2002)
3.	Hulten, Kristina G: 9 articles (04/2015 - 03/2005)
4.	Fowler, Vance G: 8 articles (12/2015 - 02/2005)
5.	Cunha, Burke A: 8 articles (08/2015 - 11/2005)
6.	Hammerman, Wendy A: 8 articles (11/2013 - 07/2003)
7.	Hsueh, Po-Ren: 8 articles (06/2013 - 03/2008)
8.	Soriano, Alex: 7 articles (11/2015 - 02/2009)
9.	Rello, Jordi: 7 articles (03/2015 - 10/2002)
10.	Sakoulas, George: 7 articles (10/2014 - 01/2003)

Related Diseases

1.	Infection 06/01/2008 - "We report a significant reduction in the number of surgical site infections (SSIs) due to meticillin-resistant Staphylococcus aureus (MRSA) in patients undergoing cardiac surgery after the introduction of preoperative screening using a same-day polymerase chain reaction (PCR) test. " 05/29/1982 - "There is controversy regarding methods employed for the detection of methicillin resistance in Staphylococcus aureus, and dispute whether infections caused by these organisms can be successfully treated with methicillin or similar antibiotic agents. " 05/01/2013 - "Despite a large body of work evaluating the ability of meticillin-resistant Staphylococcus aureus (MRSA) screening and decolonization to decrease the risk of MRSA infection and transmission, many uncertainties remain regarding the efficacy of this strategy in hospitals located in endemic areas. " 07/01/2008 - "This article will examine a range of evidence applicable to perioperative infection control and prevention, including an assessment of current practice and how it may be improved, with a particular emphasis on surgical site infection associated with Meticillin Resistant Staphylococcus Aureus (MRSA) and Clostridium Difficile (C.diff)." 07/01/1993 - "Those episodes which responded well to the VCM treatment included 10 episodes in 8 children with methicillin-resistant Staphylococcus aureus infections, 4 in 2 children with methicillin-resistant Staphylococcus epidermidis (MRSE) infections and 2 in 2 children with methicillin-susceptible S. "
2.	Endocarditis 08/26/1961 - "Staphylococcal endocarditis: report of a case cured by dimethoxyphenyl penicillin." 09/01/1994 - "Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. " 06/01/1979 - "In this study, methicillin had the same activity against experimental endocarditis caused by a tolerant and a nontolerant strain of S. " 01/01/2015 - "The most common etiological microbial agent of infective endocarditis (IE) in IVDU is Methicillin sensitive Staphylococcus aureus. " 01/01/2015 - "A case of primary infectious endocarditis with the lesion of mitral valve in a pregnant woman is reported The diseases was caused by meticillin-resistant Staphylococcus aureus. "
3.	Staphylococcal Infections 12/01/2009 - "When a staphylococcal infection is suspected but the resistance phenotype is not known, agents that are effective against methicillin-susceptible S. " 12/01/2004 - "Community-acquired staphylococcal infections may be treated with agents effective against methicillin-sensitive strains." 07/16/2014 - "Resistance to the most common antimicrobials tested for in published studies and important for the treatment of staphylococcal infections in dogs were assessed separately for methicillin resistant (MRSP) and methicillin susceptible (MSSP) isolates. " 08/01/2012 - "The increasing incidence and implications of staphylococcal infections, particularly meticillin-resistant staphylococcal infections, is leading to more interest in infection control in veterinary hospitals as a means to help reduce the impact of these significant pathogens. " 08/15/2008 - "Prior staphylococcal infection (methicillin-susceptible S. "
4.	Cross Infection (Nosocomial Infection) 01/01/2007 - "Although the association between environmental surfaces contaminated with meticillin-resistant Staphylococcus aureus (MRSA) and hospital infection rates is not fully understood, monitoring programmes can provide an objective starting point for the development and assessment of infection control strategies incorporating improved cleaning. " 09/25/1993 - "[Clinical epidemiology of an outbreak of nosocomial infections by Staphylococcus aureus resistant to methicillin and aminoglucosides: efficacy of the measures of control]." 07/01/2011 - "A total of 30 S.aureus [16 were methicillin-resistant (MRSA), 14 were methicillin-susceptible (MSSA)] and 21 Enterococcus spp. (13 E.faecalis, 7 E.faecium, 1 non-typable Enterococcus spp.) strains isolated from clinical samples of hospitalized patients as nosocomial infection agents in the Central Microbiology Laboratory of Ibn-i Sina Hospital, Ankara University, Faculty of Medicine, were included in the study. " 11/01/2015 - "Meticillin-resistant Staphylococcus aureus (MRSA) is an important pathogen associated with community-acquired and nosocomial infections. " 08/01/2015 - "Meticillin-resistant Staphylococcus aureus (MRSA) is a common cause of nosocomial infection in the intensive care unit (ICU). "
5.	Osteomyelitis 06/01/2014 - "In this experimental study, we aimed to test our hypothesis that the use of ESW together with systemic antibiotic treatment will provide synergy for the treatment of implant-related chronic osteomyelitis caused by methicillin-susceptible Staphylococcus aureus (MSSA). " 06/01/2013 - "In this study, we investigated the antibacterial property of L-PRP gel against Methicillin-resistive Staphylococcus aureus (MRSA, ATCC 43300) in a rabbit model of osteomyelitis. " 05/01/2009 - "The aim of this study was to compare the outcomes of surgical treatment of osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) with cases caused by methicillin-sensitive Staphylococcus aureus (MSSA). " 09/01/2015 - "The outcome of calcaneal osteomyelitis caused by methicillin-sensitive S. " 06/01/2015 - "Increased severity of illness in patient with acute hematogenous osteomyelitis (AHO) with methicillin-resistant Staphylococcus aureus (MRSA) necessitates prompt intervention, but overtreatment of methicillin-sensitive S. "

Related Drugs and Biologics

1.	Vancomycin
2.	Daptomycin
3.	Rifampin (Rifampicin)
4.	Gentamicins (Gentamicin)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Nafcillin
7.	linezolid (Zyvox)
8.	Cloxacillin (Tegopen)
9.	Cefazolin (Ancef)
10.	Teicoplanin

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Microspheres (Microsphere)
3.	Sternotomy
4.	Catheters
5.	Arthroplasty