Abstract | OBJECTIVE: MATERIAL AND METHODS: Using a panel of immunoassays for CCK peptides and proCCK as well as for chromogranin A, we have examined plasma samples from 284 fasting patients with gastroenteropancreatic neuroendocrine tumors. In hyperCCKemic samples, plasma CCK was further characterized by chromatography. RESULTS: One of the patients displayed gross hyperCCKemia. She was a 58-year old woman with a pancreatic endocrine tumor, liver metastases, 500-1000-fold elevated basal CCK concentration in plasma, diarrhea, severe weight loss, recurrent peptic ulcer and bilestone attacks from a contracted gallbladder. The CCK concentrations in plasma were not affected by resection of the pancreatic tumor, but decreased to normal after hemihepatectomy with removal of the metastases. CONCLUSION:
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Authors | Jens F Rehfeld, Birgitte Federspiel, Mikkel Agersnap, Ulrich Knigge, Linda Bardram |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 51
Issue 10
Pg. 1172-8
(Oct 2016)
ISSN: 1502-7708 [Electronic] England |
PMID | 27191542
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Child
- Cholecystokinin
(blood)
- Denmark
- Female
- Gastrinoma
- Gastrins
(blood)
- Humans
- Intestinal Neoplasms
(blood, pathology)
- Liver Neoplasms
(secondary)
- Male
- Middle Aged
- Neuroendocrine Tumors
(blood, pathology)
- Pancreas
(pathology)
- Pancreatic Neoplasms
(blood, pathology)
- Rats
- Stomach Neoplasms
(blood, pathology)
- Young Adult
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