Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice.

Abstract

Emerging evidence shows that dietary agents and phytochemicals contribute to the prevention and treatment of ulcerative colitis (UC). We first reported the effects of dietary caffeic acid (CaA) on murine experimental colitis and on fecal microbiota. Colitis was induced in C57BL/6 mice by administration of 2.5% dextran sulfate sodium (DSS). Mice were fed a control diet or diet with CaA (1 mM). Our results showed that dietary CaA exerted anti-inflammatory effects in DSS colitis mice. Moreover, CaA could significantly suppress the secretion of IL-6, TNFα, and IFNγ and the colonic infiltration of CD3+ T cells, CD177+ neutrophils and F4/80+ macrophages via inhibition of the activation of NF-κB signaling pathway. Analysis of fecal microbiota showed that CaA could restore the reduction of richness and inhibit the increase of the ratio of Firmicute to Bacteroidetes in DSS colitis mice. And CaA could dramatically increase the proportion of the mucin-degrading bacterium Akkermansia in DSS colitis mice. Thus, CaA could ameliorate colonic pathology and inflammation in DSS colitis mice, and it might be associated with a proportional increase in Akkermansia.

• Authors: Zhan Zhang, Xinyue Wu, Shuyuan Cao, Li Wang, Di Wang, Hui Yang, Yiming Feng, Shoulin Wang, Lei Li
• Journal: Oncotarget (Oncotarget) Vol. 7 Issue 22 Pg. 31790-9 (May 31 2016) ISSN: 1949-2553 [Electronic] United States
• PMID: 27177331 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Caffeic Acids
• Cytokines
• Inflammation Mediators
• Dextran Sulfate
• caffeic acid

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Caffeic Acids (pharmacology)
• Colitis (chemically induced, metabolism, microbiology, prevention & control)
• Colon (drug effects, metabolism, microbiology)
• Cytokines (metabolism)
• Dextran Sulfate
• Disease Models, Animal
• Feces (microbiology)
• Female
• Gastrointestinal Microbiome (drug effects)
• Inflammation Mediators (metabolism)
• Macrophages (drug effects, metabolism)
• Mice, Inbred C57BL
• Neutrophil Infiltration (drug effects)
• Neutrophils (drug effects, metabolism)
• T-Lymphocytes (drug effects, metabolism)
• Time Factors
• Verrucomicrobia (classification, drug effects, growth & development)