Abstract | OBJECTIVE: MATERIALS AND METHODS: Acoustic radiation force impulse (ARFI) was performed in 157 patients with chronic viral hepatitis B and in 30 healthy volunteers to measure hepatic SWV (m/s) in a prospective study. Serum markers were acquired on the morning of the same day of the ARFI evaluation. Receiver operating characteristic (ROC) analysis was performed to evaluate and compare the accuracies of SWV and serum markers using METAVIR scoring from liver biopsy as a reference standard. RESULTS: The most accurate test for diagnosing fibrosis F ≥ 1 was SWV with the area under the ROC curve (AUC) of 0.913, followed by LN (0.744), HA (0.701), CIV (0.690), and PCIII (0.524). The best test for diagnosing F ≥ 2 was SWV (AUC of 0.851), followed by CIV (0.671), HA (0.668), LN (0.562), and PCIII (0.550). The best test for diagnosing F ≥ 3 was SWV (0.854), followed by CIV (0.693), HA (0.675), PCIII (0.591), and LN (0.548). The best test for diagnosing F = 4 was SWV (0.965), followed by CIV (0.804), PCIII (0.752), HA (0.744), and LN (0.662). SWV combined with HA and CIV did not improve diagnostic accuracy (AUC = 0.931 for F ≥ 1, 0.863 for F ≥ 2, 0.855 for F ≥ 3, 0.960 for F = 4). CONCLUSION:
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Authors | Jianxue Liu, Yonghao Ji, Hong Ai, Bo Ning, Junzhi Zhao, Yaoren Zhang, Guoliang Dun |
Journal | Korean journal of radiology
(Korean J Radiol)
2016 May-Jun
Vol. 17
Issue 3
Pg. 396-404
ISSN: 2005-8330 [Electronic] Korea (South) |
PMID | 27134527
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Collagen Type III
- Collagen Type IV
- Laminin
- Hyaluronic Acid
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Topics |
- Adult
- Area Under Curve
- Biomarkers
(blood)
- Case-Control Studies
- Collagen Type III
(blood)
- Collagen Type IV
(blood)
- Elasticity Imaging Techniques
- Female
- Hepatitis B, Chronic
(complications, diagnosis, pathology)
- Humans
- Hyaluronic Acid
(blood)
- Laminin
(blood)
- Liver
(diagnostic imaging, pathology, physiology)
- Liver Cirrhosis
(complications, diagnosis, pathology)
- Male
- Middle Aged
- Prospective Studies
- Pulse Wave Analysis
- ROC Curve
- Severity of Illness Index
- Young Adult
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