Abstract | INTRODUCTION: METHODS: A literature search was performed in the databases PubMed and Scopus to identify observational studies evaluating serological or molecular biomarkers for recurrence of HCC after LT using adjusted analysis to correct for confounding. RESULTS: Of 502 records, 69 mainly retrospective studies were included with a total of 15,213 patients. Of these, 41 studies were suitable for meta-analyses, which showed that the serum markers pre-transplant α- fetoprotein (AFP) (hazard ratio (HR) 2.69 [2.08-3.47]), pre-transplant des-gamma-carboxy prothrombin (DCP) (HR 5.99 [3.27-10.98]), and allelic imbalance in microsatellites in DNA of tumor tissue (HR 13.49 [3.17-57.30]) were related to recurrence. CONCLUSIONS: AFP, DCP and allelic imbalance in microsatellites may be used to predict recurrence. Together with other modalities, biomarkers may be used in future transplantation criteria to optimize selection of suitable patients.
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Authors | Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg, Allan Rasmussen |
Journal | Transplantation reviews (Orlando, Fla.)
(Transplant Rev (Orlando))
Vol. 30
Issue 3
Pg. 171-7
(07 2016)
ISSN: 1557-9816 [Electronic] United States |
PMID | 27118303
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Biomarkers, Tumor
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Topics |
- Biomarkers
- Biomarkers, Tumor
- Carcinoma, Hepatocellular
(diagnosis, surgery)
- Humans
- Liver Neoplasms
(diagnosis, surgery)
- Liver Transplantation
- Neoplasm Recurrence, Local
- Prognosis
- Retrospective Studies
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