High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial.

Abstract

UNLABELLED:

Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia.

TRIAL REGISTRATION:

Netherlands Trial Registry: 1310.

• Authors: Kitty G Snoek, Ulrike S Kraemer, Chantal A Ten Kate, Anne Greenough, Arno van Heijst, Irma Capolupo, Thomas Schaible, Joost van Rosmalen, René M Wijnen, Irwin K M Reiss, Dick Tibboel
• Journal: The Journal of pediatrics (J Pediatr) Vol. 173 Pg. 245-249.e4 (Jun 2016) ISSN: 1097-6833 [Electronic] United States
• PMID: 27079964 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Troponin T
• Natriuretic Peptide, Brain

Topics

• Biomarkers (blood)
• Bronchopulmonary Dysplasia (epidemiology)
• Extracorporeal Membrane Oxygenation (statistics & numerical data)
• Female
• Hernias, Diaphragmatic, Congenital (mortality, surgery)
• Humans
• Hypertension, Pulmonary (epidemiology)
• Infant, Newborn
• Male
• Natriuretic Peptide, Brain (blood)
• Netherlands (epidemiology)
• Prognosis
• Prospective Studies
• Severity of Illness Index
• Troponin T (blood)