Abstract | BACKGROUND: OBJECTIVE: DESIGN: RESULTS: There was a reduced risk of progression to GA with increasing intake of thiamin, riboflavin, and folate after adjusting for age, sex, and total energy intake (P-trend = 0.01, 0.03, and 0.001, respectively). After adjustment for demographic, behavioral, ocular, and genetic covariates, trends remained statistically significant for folate (P-trend = 0.007) and were borderline for thiamin (P-trend = 0.05). Riboflavin did not retain statistical significance (P-trend = 0.20). Folate was significantly associated with lower risk of incident GA among subjects homozygous for the complement component 3 (C3) R102G rs2230199 nonrisk genotype (CC) (HR = 0.43; 95% CI: 0.27, 0.70; P = 0.0005) but not subjects carrying the risk allele (G) (P = 0.76). Neither folate nor any B vitamin was significantly associated with neovascular AMD. CONCLUSIONS: High folate intake was associated with a reduced risk of progression to GA. This relation could be modified by genetic susceptibility, particularly related to the C3 genotype. This trial was registered at clinicaltrials.gov as NCT00594672.
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Authors | Bénédicte M J Merle, Rachel E Silver, Bernard Rosner, Johanna M Seddon |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 103
Issue 4
Pg. 1135-44
(Apr 2016)
ISSN: 1938-3207 [Electronic] United States |
PMID | 26961928
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- ARMS2 protein, human
- Collagen Type VIII
- Complement C2
- Complement C3
- Proteins
- Vitamin B Complex
- Complement Factor H
- Folic Acid
- High-Temperature Requirement A Serine Peptidase 1
- HtrA1 protein, human
- Serine Endopeptidases
- Complement Factor B
- Riboflavin
- Thiamine
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Topics |
- Aged
- Body Mass Index
- Collagen Type VIII
(genetics, metabolism)
- Complement C2
(genetics, metabolism)
- Complement C3
(genetics, metabolism)
- Complement Factor B
(genetics, metabolism)
- Complement Factor H
(genetics, metabolism)
- Disease Progression
- Female
- Folic Acid
(administration & dosage)
- Genetic Predisposition to Disease
- Geographic Atrophy
(genetics)
- High-Temperature Requirement A Serine Peptidase 1
- Humans
- Macular Degeneration
(genetics)
- Male
- Middle Aged
- Prospective Studies
- Proteins
(genetics, metabolism)
- Riboflavin
(administration & dosage)
- Serine Endopeptidases
(genetics, metabolism)
- Thiamine
(administration & dosage)
- Vitamin B Complex
(administration & dosage)
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