Component-resolved diagnosis in anaphylaxis.

Abstract

PURPOSE OF REVIEW:

Component-resolved diagnosis (CRD) is an advanced tool capable of aiding the clinician in fine tuning the diagnosis of the causal allergens of a reaction with the added value of providing information of severity risk, potential cross-reactivity, and subsequently, guiding management measures. This review will focus on the advantages of CRD of anaphylaxis in clinical practice.

RECENT FINDINGS:

Research is continuously providing insight to which molecules are associated with genuine sensitization and/or potential severity risk for hymenoptera venom (Api m1, Ves v 1, Ves v 5, and Pol d 5), food allergy (seed storage proteins and nonspecific lipid transfer proteins), cofactor-enhanced food allergy (ω-5-gliadine, nonspecific lipid transfer proteins), red meat delayed anaphylaxis (α-gal), latex allergy (Hev b 1, Hev b 3, Hev b 5, and Hev b 6), and Anisakis allergy (Ani s 1, Ani s 4, Ani s 7, and Ani s 13); other molecules are primary associated with nonclinically relevant sensitizations, cross-reactivity, or mild reactions (carbohydrate determinants and profilins). New molecules, some minor allergens, are being identified as new potential biomarkers of severity.

SUMMARY:

The usefulness of CRD in anaphylaxis is self-evident, since it improves the recognition of sensitization profiles associated with specific clinical outcomes and provides information to guide further management.

• Authors: Victoria Cardona, Ignacio J Ansotegui
• Journal: Current opinion in allergy and clinical immunology (Curr Opin Allergy Clin Immunol) Vol. 16 Issue 3 Pg. 244-9 (06 2016) ISSN: 1473-6322 [Electronic] United States
• PMID: 26945180 (Publication Type: Journal Article, Review)

Chemical References

• Allergens
• Immunoglobulin E

Topics

• Algorithms
• Allergens (immunology)
• Anaphylaxis (diagnosis)
• Animals
• Cross Reactions
• Humans
• Immunoglobulin E (blood)
• Practice Guidelines as Topic