Abstract | BACKGROUND: METHODS: In total, 70 patients with endoscopic disease activity available and 194 patients with disease activity on the basis of a stringent combi-score of clinical activity index, C-reactive protein, and fecal calprotectin were included. Plasma I-FABP was compared between patients with active disease and remission. In a small subgroup of CD patients, follow-up samples were analyzed. RESULTS: In CD (139.2 vs. 119.2 pg/ml; P=0.37) and UC (107.8 vs. 151.8 pg/ml; P=0.33), the median I-FABP did not differ in endoscopic active disease versus remission. In UC patients with active disease on the basis of the combi-score, the median I-FABP (106.8 vs. 172.0 pg/ml; P=0.03) was significantly lower than in patients in remission, but not in CD (145.5 vs. 157.5 pg/ml; P=0.29). Neither disease location in CD nor extent of disease in UC influenced I-FABP significantly. I-FABP was not different (P=0.78) in CD patients with a change in disease activity over time. CONCLUSION: Plasma I-FABP did not differ between endoscopic active disease and remission in both CD and UC. I-FABP was lower in active UC but not CD on the basis of the combi-score. On the basis of these findings, I-FABP has no potential as a novel noninvasive biomarker for disease activity in IBD.
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Authors | Alexander G L Bodelier, Marie J Pierik, Kaatje Lenaerts, Evelien de Boer, Steven W Olde Damink, Wim M Hameeteman, Ad A M Masclee, Daisy M Jonkers |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 28
Issue 7
Pg. 807-13
(Jul 2016)
ISSN: 1473-5687 [Electronic] England |
PMID | 26919325
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Fatty Acid-Binding Proteins
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Topics |
- Adult
- Biomarkers
(blood)
- Colitis, Ulcerative
(diagnosis, pathology)
- Crohn Disease
(diagnosis, pathology)
- Endoscopy, Gastrointestinal
(methods)
- Fatty Acid-Binding Proteins
(blood)
- Female
- Follow-Up Studies
- Humans
- Inflammatory Bowel Diseases
(diagnosis, pathology, therapy)
- Male
- Middle Aged
- Prospective Studies
- Remission Induction
- Severity of Illness Index
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