Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis.

Abstract

AIMS:

Superoxide dismutase 2 (SOD2) is an important antioxidant phase 2 enzyme. The associations of SOD2 genetic variation and the risk of advanced alcoholic liver diseases are still debatable. We aimed to investigate the association of the main SOD2 genetic variant (47T>C) and the susceptibility to alcoholic cirrhosis.

METHODS:

A total of 80 patients with alcoholic cirrhosis (AC), 80 patients with alcoholic non-cirrhosis (ANC), 80 with viral hepatitis B-related cirrhosis (VC), and 165 healthy controls (HC) were enrolled into this study. A polymerase chain reaction was used to genotype their SOD2 47T>C (rs4880).

RESULTS:

There was no statistical difference in the frequency distribution of the three SOD2 47T>C genotypes among groups. However, if individuals with C variant were grouped together, the AC group had higher frequency of SOD2 C/C or C/T genotype than ANC, VC and HC groups had (38.7% vs. 21.3%, 26.3% and 21.8%, respectively, P = 0.010). After adjustment for confounders, the SOD2 C/C and C/T genotypes remained associated with the risk of AC (adjusted OR: 2.79 and 3.50, respectively, P < 0.03, compared with ANC and HC groups). In contrast, there was no significant difference of SOD2 genetic variation between VC and HC groups.

CONCLUSIONS:

Anti-oxidative enzyme SOD2 47T>C genetic variant may increase the susceptibility to AC. This suggests that oxidative stress plays a role in the development of AC.

• Authors: Yi-Shin Huang, Li Yueh Wang, Chih-Hao Chang, Chin-Lin Perng, Han-Chieh Lin
• Journal: Alcohol and alcoholism (Oxford, Oxfordshire) (Alcohol Alcohol) Vol. 51 Issue 6 Pg. 633-637 (Nov 2016) ISSN: 1464-3502 [Electronic] England
• PMID: 26873981 (Publication Type: Journal Article)
• Copyright: © The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved.

Chemical References

• Superoxide Dismutase
• superoxide dismutase 2

Topics

• Case-Control Studies
• Female
• Genetic Predisposition to Disease (genetics)
• Hepatitis B (genetics)
• Humans
• Liver Cirrhosis (genetics, virology)
• Liver Cirrhosis, Alcoholic (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors
• Superoxide Dismutase (genetics, physiology)