IPN hydrogel nanocomposites based on agarose and ZnO with antifouling and bactericidal properties.

Abstract

Nanocomposite hydrogels with interpenetrating polymer network (IPN) structure based on poly(ethylene glycol) methyl ether methacrylate modified ZnO (ZnO-PEGMA) and 4-azidobenzoic agarose (AG-N3) were prepared by a one-pot strategy under UV irradiation. The hydrogels exhibited a highly macroporous spongelike structure, and the pore size decreased with the increase of the ZnO-PEGMA content. Due to the entanglement and favorable interactions between the two crosslinked networks, the IPN hydrogels exhibited excellent mechanical strength and light transmittance. The maximum compressive and tensile strengths of the IPN hydrogels reached 24.8 and 1.98 MPa respectively. The transparent IPN hydrogels transmitted more than 85% of visible light at all wavelengths (400-800 nm). The IPN hydrogels exhibited anti-adhesive property towards Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), and the bactericidal activity increased with the ZnO-PEGMA content. The incorporation of ZnO-PEGMA did not reduce the biocompatibility of the IPN hydrogels and all the IPN nanocomposites showed negligible cytotoxicity. The present study not only provided a facile method for preparing hydrogel nanocomposites with IPN structure but also developed a new hydrogel material which might be an excellent candidate for wound dressings.

• Authors: Jingjing Wang, Hongkai Hu, Zhonglin Yang, Jun Wei, Juan Li
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 61 Pg. 376-86 (Apr 01 2016) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 26838864 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Biocompatible Materials
• Hydrogels
• Polymers
• Water
• Sepharose
• Zinc Oxide

Topics

• Animals
• Anti-Bacterial Agents (chemistry, pharmacology)
• Bacterial Adhesion (drug effects)
• Biocompatible Materials (chemistry, pharmacology, toxicity)
• Cell Line
• Cell Survival (drug effects)
• Escherichia coli (drug effects)
• Hydrogels (chemistry)
• Light
• Mice
• Microscopy, Electron, Scanning
• Nanocomposites (chemistry)
• Permeability
• Polymers (chemistry)
• Porosity
• Sepharose (chemistry)
• Spectroscopy, Fourier Transform Infrared
• Staphylococcus aureus (drug effects)
• Water (chemistry)
• Zinc Oxide (chemistry)