Abstract | BACKGROUND: The availability of simple and accurate assays of plasma active renin (DRC) and aldosterone concentration (PAC) can improve the detection of secondary forms of arterial hypertension. Thus, we investigated the performance of an automated chemiluminescent assay for DRC and PAC in referred hypertensive patients. METHODS: RESULTS: At Bland-Altman plot, the DRC and PAC assay showed no bias as compared to the PRA and PAC assay. A tight relation was found between the DRC and the PRA values (concordance correlation coefficient=0.92, p<0.0001) and the PAC values measured with radioimmunoassay and chemiluminescence (concordance correlation coefficient=0.93, p<0.001). For APA identification the AUC of the ARRCL was higher than that of the ARRRIA [0.974 (95% CI 0.940-0.991) vs. 0.894 (95% CI 0.841-0.933), p=0.02]. CONCLUSIONS: This rapid automated chemiluminescent DRC/PAC assay performed better than validated PRA/PAC radioimmunoassays for the identification of APA in referred hypertensive patients.
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Authors | Gian Paolo Rossi, Giulio Ceolotto, Giacomo Rossitto, Teresa Maria Seccia, Giuseppe Maiolino, Chiara Berton, Daniela Basso, Mario Plebani |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 54
Issue 9
Pg. 1441-50
(Sep 01 2016)
ISSN: 1437-4331 [Electronic] Germany |
PMID | 26824982
(Publication Type: Journal Article, Validation Study)
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Chemical References |
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Topics |
- Adult
- Aldosterone
(blood)
- Automation
- Female
- Humans
- Hypertension
(blood, diagnosis)
- Luminescence
- Male
- Middle Aged
- Prospective Studies
- Renin
(blood)
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