Abstract | PURPOSE: To evaluate frequency of migraine, vasospasm (VS), family history (FH) of migraine, and family history of glaucoma (FHG) in different types of glaucoma in relation to age and stage of visual field loss (VFL) at diagnosis. METHODS: RESULTS: Of all patients, 13.7% reported migraine, 19.0% VS, 30.8% FH of migraine, and 40.3% FHG. Patients with FHG had a significantly higher frequency of migraine than patients without FHG (15.7% vs. 12.3%, P = 0.02). Migraine was significantly more frequent in NTG (21.4%) than POAG (13.1%; P = 0.01), PEX (7.8%; P = 0.02), and PACG (10.1%; P = 0.004). Compared to patients with POAG, patients with NTG had a 63.5% higher age-corrected probability for migraine (P = 0.007). There was no evidence for migraine or VS being prognostic factors regarding the extent of VFL at diagnosis. Migraine and VS were significantly more frequent in females. CONCLUSIONS: The higher frequency of migraine and VS in females could contribute to the female preponderance in NTG. Our findings suggest an association of NTG and migraine and a common, possibly polygenetic, vascular etiology of these two diseases both with familial predisposition.
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Authors | Gwendolyn Gramer, Bernhard H F Weber, Eugen Gramer |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 56
Issue 13
Pg. 7999-8007
(Dec 2015)
ISSN: 1552-5783 [Electronic] United States |
PMID | 26720447
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Female
- Glaucoma
(etiology)
- Humans
- Male
- Middle Aged
- Migraine Disorders
(complications)
- Ocular Hypertension
(etiology)
- Prospective Studies
- Risk Factors
- Sex Factors
- Vasospasm, Intracranial
(complications)
- Vision Disorders
(etiology)
- Visual Fields
(physiology)
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