Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.

Abstract

An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.

• Authors: L Zuccaro, A Cox, C Pray, K Radford, K Novakowski, M Dorrington, M G Surette, D Bowdish, P Nair
• Journal: Allergy (Allergy) Vol. 71 Issue 4 Pg. 571-5 (Apr 2016) ISSN: 1398-9995 [Electronic] Denmark
• PMID: 26715426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Topics

• Adolescent
• Adult
• Aged
• Asthma (complications, diagnosis, metabolism)
• Bacterial Infections (complications, microbiology)
• Bronchitis (complications, microbiology)
• Child
• Female
• Humans
• Male
• Middle Aged
• Severity of Illness Index
• Sputum (enzymology, immunology)
• Young Adult