Abstract | OBJECTIVE: To evaluate the evidence for the use of intravenous ketamine for analgosedation in the intensive care unit. METHODS: RESULTS: One trial evaluated opioid consumption as an outcome in postoperative critically ill patients who were randomized to ketamine or saline infusions. The mean cumulative morphine consumption at 48 hours was significantly lower in the ketamine group (58 ± 35 mg) compared to the morphine-only group (80 ± 37 mg; P < .05). Other trials showed the potential safety of ketamine in terms of cerebral hemodynamics in patients with traumatic brain injury, improved gastrointestinal motility, and decreased vasopressor requirements. The observational study and case reports suggest that ketamine is safe and effective and may have a role in patients who are refractory to other therapies. CONCLUSION:
Ketamine use may decrease analgesic consumption in the intensive care unit. Additional trials are needed to further delineate the role of ketamine for analgosedation.
|
Authors | Asad E Patanwala, Jennifer R Martin, Brian L Erstad |
Journal | Journal of intensive care medicine
(J Intensive Care Med)
Vol. 32
Issue 6
Pg. 387-395
(Jul 2017)
ISSN: 1525-1489 [Electronic] United States |
PMID | 26647407
(Publication Type: Journal Article, Review, Systematic Review)
|
Chemical References |
|
Topics |
- Analgesics
(therapeutic use)
- Critical Care
- Critical Illness
(therapy)
- Humans
- Infusions, Intravenous
- Intensive Care Units
- Ketamine
(therapeutic use)
- Observational Studies as Topic
- Randomized Controlled Trials as Topic
- Treatment Outcome
|