Abstract | BACKGROUND: The association between abacavir use and increased risk of myocardial infarction has been heavily debated, but cohort studies and randomized trials have provided conflicting results. Aim of our study is to compare the effect of abacavir and tenofovir on the inflammation and endothelial activation markers. METHODS: RESULTS: As a whole, 118 patients (93 males; mean age ± SD of 42.8 ± 10.1 years) were enrolled: 61 in group A and 57 in group B. In group A at weeks 24 and 48 the mean concentrations of IL-6, TNF-α, ICAM-1, VCAM-1, E-selectin and Pselectin decreased significantly in comparison with respective baseline values. In group B at week 24 a significant increase in mean values of these markers was reported in comparison with group A, but after 48 weeks they significantly decreased in group B too and no significant differences between groups A and B were found. CONCLUSION:
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Authors | Leonardo Calza, Eleonora Magistrelli, Ilaria Danese, Vincenzo Colangeli, Marco Borderi, Isabella Bon, Maria Carla Re, Rita Mancini, Matteo Conti, Roberto Motta, Pierluigi Viale |
Journal | Current HIV research
(Curr HIV Res)
Vol. 14
Issue 1
Pg. 61-70
( 2016)
ISSN: 1873-4251 [Electronic] Netherlands |
PMID | 26531764
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Alkynes
- Anti-HIV Agents
- Benzoxazines
- Biomarkers
- Cyclopropanes
- Dideoxynucleosides
- Drug Combinations
- E-Selectin
- Interleukin-6
- P-Selectin
- Tumor Necrosis Factor-alpha
- Vascular Cell Adhesion Molecule-1
- abacavir, lamivudine drug combination
- Intercellular Adhesion Molecule-1
- Lamivudine
- Tenofovir
- Emtricitabine
- efavirenz
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Topics |
- Adult
- Alkynes
- Anti-HIV Agents
(adverse effects, therapeutic use)
- Benzoxazines
(adverse effects, therapeutic use)
- Biomarkers
(blood)
- Cyclopropanes
- Dideoxynucleosides
(adverse effects, therapeutic use)
- Drug Combinations
- E-Selectin
(blood)
- Emtricitabine
(adverse effects, therapeutic use)
- Female
- HIV Infections
(blood, drug therapy)
- Humans
- Inflammation
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-6
(blood)
- Lamivudine
(adverse effects, therapeutic use)
- Male
- Middle Aged
- P-Selectin
(blood)
- Tenofovir
(adverse effects, therapeutic use)
- Tumor Necrosis Factor-alpha
(blood)
- Vascular Cell Adhesion Molecule-1
(blood)
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